Science Daily: Pharmacology News

JUNE 24, 2024

Researchers have harnessed a bacterial immune defense system, known as CRISPR, to efficiently and precisely control the process of RNA splicing.

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RNA Research Disease 117

Science Daily: Pharmacology News

NOVEMBER 21, 2024

Researchers have developed a groundbreaking microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains. The new method, called TRISCO, has the potential to transform our understanding of brain function, both in normal conditions and in disease, according to the new study.

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RNA Disease Research 109

Chemical Biology and Drug Design

DECEMBER 13, 2023

This up-to-date commentary/perspective article sheds light on the revolutionary approaches designed to target the principal viral weapon “RNA” used by RNA viruses (e.g., the severe acute respiratory syndrome coronavirus 2 “SARS-CoV-2”) to infect humans and spread infections, the genomic RNA strands.

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RNA Disease Virus Drugs 100

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

By adding synergistic self-adjuvanting properties to Covid-19 RNA vaccines, researchers showed they could significantly boost the immune response generated in mice.

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RNA Vaccine Engineering Immune Response 94

Drug Target Review

JUNE 15, 2023

In this article Drug Target Review’s Izzy Wood spoke to Sam Hasson, Director of Target Biology at Rgenta Therapeutics, a biotech firm in Massachusetts, US, that aims to develop small molecule therapeutics to target RNA processing. The field is faced with a number of obstacles that require specifically assay technologies to surmount.

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RNA Small Molecule Disease Assay Development 96

Science Daily: Pharmacology News

SEPTEMBER 19, 2023

A new study shows the isolation and sequencing of more than a century-old RNA molecules from a Tasmanian tiger specimen preserved at room temperature in a museum collection. This resulted in the reconstruction of skin and skeletal muscle transcriptomes from an extinct species for the first time.

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RNA Virus International Research 97

SCIENMAG: Medicine & Health

AUGUST 14, 2023

A technique that enables scientists to record gene mutations and patterns of gene activity in individual cells has been extended to cover RNA splicing as well, in a study led by researchers at Weill Cornell Medicine, the New York Genome Center and the Princess Margaret Cancer Centre in Toronto.

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RNA Disease Research 83

BioPharma Drive: Drug Pricing

JUNE 18, 2024

While the Swiss pharma recently pruned its neurology drug pipeline, it has shown interest in the possibilities of RNA-focused approaches like what Ascidian is exploring.

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RNA Drugs 72

Drug Discovery Today

MAY 10, 2021

A new approach to tackling viruses by targeting the ‘control centre’ in viral RNA could lead to broad spectrum anti-viral drugs and provide a first line of defence against future pandemics, according to new research at the University of Birmingham.

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RNA Virus Drugs Research 100

SCIENMAG: Medicine & Health

AUGUST 3, 2023

The Access to Advanced Health Institute Receives $18 Million Award to Develop a Temperature Stable, Single-Dose Chikungunya RNA Vaccine Through a Phase 1 Clinical Trial Credit: Delaney Brown Photography The Access to Advanced Health Institute Receives $18 Million Award to Develop a Temperature Stable, Single-Dose Chikungunya RNA Vaccine Through a Phase (..)

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RNA Clinical Trials Vaccine Trials 93

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory.

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RNA Production Molecular Biology Laboratories 84

SCIENMAG: Medicine & Health

JULY 19, 2023

Together, they have published dozens of papers on the mechanics of mitochondrial DNA and RNA in a single-celled, disease-causing parasite called Trypanosoma brucei. As molecular biologists at Boston University and as husband and wife, Ruslan Afasizhev and Inna Afasizheva, have worked together for decades.

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RNA Disease DNA 83

BioPharma Drive: Drug Pricing

JULY 31, 2024

Launched last September, the company is working on a treatment for alpha-1 antitrypsin deficiency, which it said could enter the clinic in 2025.

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RNA Treatment 119

BioPharma Drive: Drug Pricing

JANUARY 3, 2024

The deal is the third Roche has formed with startups developing pills that target RNA, following similar pacts with Arrakis and Ribometrix.

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RNA Drugs 75

BioPharma Drive: Drug Pricing

SEPTEMBER 5, 2023

The biotech, one of several advancing RNA editing medicines, expects to obtain “proof-of-mechanism” data in patients with the inherited disorder alpha-1 antitrypsin deficiency by next year.

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RNA Therapies 75

BioPharma Drive: Drug Pricing

SEPTEMBER 27, 2023

The Swiss drugmaker is restocking its pipeline by buying into preclinical Ionis medicines for Alzheimer’s and Huntington’s diseases.

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RNA Disease 122

BioPharma Drive: Drug Pricing

APRIL 22, 2024

billion, is the latest research collaboration involving small molecule drugs that modify RNA. The deal, which could be worth up to $1.8

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RNA Small Molecule Disease Research 69

Crown Bioscience

JULY 15, 2024

In the world of RNA analysis, researchers have an array of technologies at their disposal. In this post, we'll delve into three popular RNA analysis methods— transcriptome-wide RNA-Seq, Nanostring nCounter, and targeted RNA-Seq panels—comparing their features and discussing when to use each.

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RNA Research 52

Drug Target Review

JANUARY 24, 2024

Scientists from Northwestern Medicine have demonstrated that RNA interference could have a crucial role in the onset and development of Alzheimer’s disease (AD). sRNAs Cellular functions rely on numerous protein-coding and noncoding RNAs and the RNA-binding proteins associated with them, which form ribonucleoprotein complexes (RNPs).

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RNA Disease DNA Engineering 64

Covalent Modifiers

FEBRUARY 25, 2024

TD19 irreversibly modifies the residues C100 and C267, preventing ALKBH5 from binding to m6A-containing RNA. Moreover, TD19 displays good anticancer efficacy in acute myeloid leukemia and glioblastoma multiforme cell lines.

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RNA Cell Based Assays Regulations Research 63

Fierce BioTech

NOVEMBER 5, 2024

Single Cell RNA Profiling FFPE Tissue Explore the robust cross-platform agreement between scRNA-seq and bulk RNA-seq, ensuring consistent and reproducible data on immune cell presence. Quality control metrics highlight the optimal conditions for processing FFPE curls, with the highest DV200 samples yielding the most robust data.

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RNA Laboratories 52

BioPharma Drive: Drug Pricing

SEPTEMBER 19, 2023

AIRNA is one of several biotechs to debut plans for target alpha-1 antitrypsin deficiency in recent years, with competitors such as AlveoGene, Wave Life Sciences and Arrowhead Pharmaceuticals.

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RNA Disease Science Pharmaceuticals 126

Drug Target Review

DECEMBER 6, 2023

Dear readers, RNA, or ribonucleic acid, plays a pivotal role in the intricate dance of cellular processes. We are committed to providing you with the highest quality content, and we believe that this report will deliver a different perspective on the topics covered.

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RNA DNA Vaccine Drug Development 52

BioPharma Drive: Drug Pricing

NOVEMBER 6, 2024

Pioneers like Alnylam Pharmaceuticals have led the RNA interference field for years. Now, a crop of young biotechs is building on that foundation by taking the drugmaking technology in new directions.

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RNA Pharmaceuticals 139

Broad Institute

JUNE 28, 2023

They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells. The new study demonstrates that RNA-guided DNA-cutting mechanisms are present across all kingdoms of life. said Zhang.

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RNA DNA Research Engineering 139

Drug Target Review

JANUARY 2, 2024

Forging the toolkit for subcellular omics Cellular components known as organelles, consisting of RNA and protein, exert vital influences on human wellbeing and ailments by sustaining equilibrium, managing growth and ageing, and producing energy.

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RNA Immune Response Therapies Disease 128

Science Daily: Pharmacology News

AUGUST 21, 2024

billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived. New research shows that rainwater could have helped create a meshy wall around protocells 3.8

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RNA Research 137

Science Daily: Pharmacology News

AUGUST 2, 2024

A team has demonstrated a mechanism that could have enabled the first RNA molecules to stabilize in the primordial soup. When two RNA strands combine, their stability and lifespan increase significantly. How were complex molecules able to form and remain intact for prolonged periods without disintegrating?

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RNA 119

BioPharma Drive: Drug Pricing

JULY 14, 2023

The deal with Frequency Therapeutics is the latest biotech reverse merger as private drugmakers still face challenges going public via an IPO.

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RNA 98

BioPharma Drive: Drug Pricing

JUNE 17, 2024

Elevate precision medicine: dose optimization and immune monitoring through advanced liquid biopsies.

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Clinical Trials RNA Trials 111

BioPharma Drive: Drug Pricing

JULY 17, 2023

For $500 million, Novartis will acquire DTx Pharma and its preclinical neurological disease drugs, marking the Swiss company’s latest investment in gene-silencing medicines.

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RNA Drugs Disease 98

Science Daily: Pharmacology News

OCTOBER 9, 2024

161,979 new RNA viruses have been discovered using a machine learning tool that researchers believe will vastly improve the mapping of life on Earth and could aid in the identification of many millions more viruses yet to be characterized.

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Virus RNA Research 130

Science Daily: Pharmacology News

AUGUST 30, 2024

The team discovered that an RNA molecule, rather than a protein as previously thought, plays a pivotal role in determining the distribution of black pigment on butterfly wings. Researchers have uncovered a surprising genetic mechanism that influences the vibrant and complex patterns on butterfly wings.

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RNA Research 130

Broad Institute

APRIL 4, 2024

A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis By Rose Circeo April 4, 2024 Breadcrumb Home A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

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RNA Bioethics Disease Research 52

Science Daily: Pharmacology News

JUNE 8, 2023

The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins. Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions.

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RNA DNA Research 144

BioPharma Drive: Drug Pricing

JUNE 25, 2024

The company claims it can address some of the field’s limitations with medicines delivered via messenger RNA and lipid nanoparticles.

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RNA 119

SCIENMAG: Medicine & Health

JUNE 30, 2023

“[…] we see our work as an indication that combining different molecular data types could be a general strategy to improve future aging clocks.” Credit: 2023 Salignon et al. “[…] we see our work as an indication that combining different molecular data types could be a general strategy to improve future aging clocks.”

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RNA 93