Science Daily: Pharmacology News

SEPTEMBER 19, 2023

A new study shows the isolation and sequencing of more than a century-old RNA molecules from a Tasmanian tiger specimen preserved at room temperature in a museum collection. This resulted in the reconstruction of skin and skeletal muscle transcriptomes from an extinct species for the first time.

RNA 240

RNA Virus International Research 240

BioPharma Drive: Drug Pricing

SEPTEMBER 19, 2023

AIRNA is one of several biotechs to debut plans for target alpha-1 antitrypsin deficiency in recent years, with competitors such as AlveoGene, Wave Life Sciences and Arrowhead Pharmaceuticals.

RNA 300

RNA Disease Science Pharmaceuticals 300

Broad Institute

FEBRUARY 27, 2025

An ancient RNA-guided system could simplify delivery of gene editing therapies By Corie Lok February 27, 2025 Breadcrumb Home An ancient RNA-guided system could simplify delivery of gene editing therapies The programmable proteins are compact, modular, and can be directed to modify DNA in human cells. Lisa Yang and Hock E.

RNA 66

RNA Therapies DNA Virus 66

Science Daily: Pharmacology News

AUGUST 21, 2024

billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived. New research shows that rainwater could have helped create a meshy wall around protocells 3.8

RNA 341

RNA Research 341

Science Daily: Pharmacology News

AUGUST 2, 2024

A team has demonstrated a mechanism that could have enabled the first RNA molecules to stabilize in the primordial soup. When two RNA strands combine, their stability and lifespan increase significantly. How were complex molecules able to form and remain intact for prolonged periods without disintegrating?

RNA 294

RNA 294

BioPharma Drive: Drug Pricing

JUNE 3, 2024

With new modalities such as gene and cell therapies, RNA therapeutics, complex biologics and more, today’s science brings unprecedented opportunities to address diseases that have long remained out of reach.

Science 139

Science RNA Therapies Disease 139

Science Daily: Pharmacology News

OCTOBER 9, 2024

161,979 new RNA viruses have been discovered using a machine learning tool that researchers believe will vastly improve the mapping of life on Earth and could aid in the identification of many millions more viruses yet to be characterized.

Virus 323

Virus RNA Research 323

Science Daily: Pharmacology News

AUGUST 30, 2024

The team discovered that an RNA molecule, rather than a protein as previously thought, plays a pivotal role in determining the distribution of black pigment on butterfly wings. Researchers have uncovered a surprising genetic mechanism that influences the vibrant and complex patterns on butterfly wings.

RNA 323

RNA Research 323

Science Daily: Pharmacology News

JUNE 8, 2023

The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins. Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions.

RNA 361

RNA DNA Research 361

Science Daily: Pharmacology News

JANUARY 29, 2025

Scientists detected all five nucleobases -- building blocks of DNA and RNA -- in samples returned from asteroid Bennu by NASA's OSIRIS-REx mission.

RNA 294

RNA DNA 294

BioPharma Drive: Drug Pricing

JANUARY 23, 2024

J&J and Bristol Myers joined the latest funding round for the startup, which was led by the newly launched Mirae Asset Capital Life Science.

RNA 164

RNA Science Drugs 164

Science Daily: Pharmacology News

MAY 29, 2024

Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix. New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.'

RNA 296

RNA DNA Therapies Treatment 296

Science Daily: Pharmacology News

JANUARY 16, 2024

RNA is thought to have sparked the origin of life by self-copying. Researchers have now revealed the atomic structure of an 'RNA copy machine' through cryo-EM. This breakthrough sheds light on a primordial RNA world and fuels advancements in RNA nanotechnology and medicine.

RNA 232

RNA Research 232

Broad Institute

MARCH 12, 2025

Related group Spatial Technology Platform Related news Q&A: How a Broad team uses cutting-edge spatial technologies to enable new science Recently, scientists have been able to explore gene circuitry in individual cells using methods that suppress particular genes and measure the impact on the expression of other genes.

RNA 99

RNA Science Research Disease 99

Drug Target Review

JUNE 15, 2023

In this article Drug Target Review’s Izzy Wood spoke to Sam Hasson, Director of Target Biology at Rgenta Therapeutics, a biotech firm in Massachusetts, US, that aims to develop small molecule therapeutics to target RNA processing. The field is faced with a number of obstacles that require specifically assay technologies to surmount.

RNA 96

RNA Small Molecule Disease Assay Development 96

Science Daily: Pharmacology News

JULY 27, 2023

In a step forward in the development of genetic medicines, researchers have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

RNA 183

RNA Research Therapies Disease 183

Science Daily: Pharmacology News

DECEMBER 20, 2023

A research team has uncovered a previously undetected mechanism in mice -- starring the genetic molecule RNA -- that could explain how each sensory cell, or neuron, in mammalian noses becomes tailored to detect a specific odor chemical.

RNA 240

RNA Research 240

Science Daily: Pharmacology News

NOVEMBER 7, 2024

Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins. But only two percent of the human genome actually encodes proteins; the function of the remaining 98 percent remains largely unknown.

RNA 244

RNA DNA 244

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory.

RNA 84

RNA Production Molecular Biology Laboratories 84

Science Daily: Pharmacology News

AUGUST 30, 2023

Researchers applied a new technology to generate the full inventory of mutations in the bacterial species Escherichia coli where the antibiotic rifampicin attaches to and disables an essential bacterial enzyme known as RNA polymerase (RNAP).

Engineering 208

Engineering RNA Research 208

Elrig

MARCH 25, 2025

This second ELRIG meeting on Therapeutic Oligonucleotides brings together esteemed scientists from academia, industry, and other members of the drug discovery community to explore the discovery, validation, and targeting of oligonucleotide-based drug candidates, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).

RNA 59

RNA Bioinformatics Science Pharmacokinetics 59

Science Daily: Pharmacology News

JULY 5, 2023

This breakthrough was possible because of the novel findings, also presented in the study, that aberrant alternative splicing of messenger RNA (mRNA) plays a principal role in fragile X syndrome, the most common form of inherited intellectual disability and the most frequent single-gene cause of autism.

Protein Production 189

Protein Production Production Therapies RNA 189

Drug Target Review

DECEMBER 6, 2024

This includes verifying the experimental design and understanding how the data was generated whether it was from RNA sequencing, mass spectrometry, or other biological assays. About the authors Dr Raminderpal Singh Dr Raminderpal Singh is a recognised visionary in the implementation of AI across technology and science-focused industries.

RNA 52

RNA Drugs Research Science 52

Drug Target Review

DECEMBER 6, 2023

Dear readers, RNA, or ribonucleic acid, plays a pivotal role in the intricate dance of cellular processes. We are committed to providing you with the highest quality content, and we believe that this report will deliver a different perspective on the topics covered.

RNA 52

RNA DNA Vaccine Drug Development 52

PLOS: DNA Science

JUNE 8, 2023

What I love most about science in general, and genetics in particular, is when new findings upend everything we thought we knew about something. But some species control genetic responses another way – via RNA editing. Because the edits are in RNA, and not DNA, they are fleeting. ’ ” Rosenthal posed.

RNA 52

RNA DNA Science Laboratories 52

Broad Institute

NOVEMBER 23, 2023

The work appears today in Science. The scientists found a surprising number and diversity of CRISPR systems, including ones that could make edits to DNA in human cells, others that can target RNA, and many with a variety of other functions. They studied several of the new systems in greater detail in the lab. Online November 23, 2023.

RNA 135

RNA DNA Engineering Science 135

Dark Matter Blog

AUGUST 31, 2020

Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA. Today, we are pleased to announce that our article describing one such platform: “ PEARL-seq, A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions ” was published in ACS Chemical Biology.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Broad Institute

FEBRUARY 26, 2025

To address these challenges, we introduce a data-driven tree-based framework that incorporates uncertainty into RNA-seq data analysis. In the first part of the talk, I will discuss existing approaches for handling uncertainty and their limitations in RNA-seq data analysis before introducing TreeTerminus.

RNA 52

RNA Bioinformatics Science International 52

Broad Institute

SEPTEMBER 23, 2024

Using what they learned from these experiments, they developed a framework — ligation-enabled messenger RNA-oligonucleotide assembly, or LEGO — that enables researchers to chemically modify the structure of mRNA molecules and influence their interactions with the cell's protein-translation machinery, achieving desired therapeutic effects.

RNA 134

RNA Vaccine Small Molecule Therapies 134

The Pharma Data

JANUARY 5, 2021

Durham, North Carolina-based Ribometrix announced a strategic collaboration deal with Genentech , a Roche company, to identify and advance novel RNA-targeted small molecule therapeutics. Targeting RNA is believed to be a way to develop therapeutics for so-called undruggable proteins. The first identifies the 3D RNA motifs.

RNA 52

RNA Small Molecule DNA Licensing 52

Sygnature Discovery

SEPTEMBER 12, 2024

We’ve successfully tackled targets for: Unprecedented membrane proteins Intrinsically disordered proteins Refolding from inclusion bodies Large protein complexes Labelled proteins for NMR studies RNA structures by crystallography Across our capabilities Construct Design Structure-guided sequence design.

Science 52

Science Protein Production RNA Packaging 52

Drug Target Review

JULY 24, 2023

The results were published in Proceedings of National Academy of Sciences of United States of America (PNAS). Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma. The first identification was based on a bioinformatic analysis.

RNA 98

RNA Regulations Bioinformatics Laboratories 98

Codon

JANUARY 24, 2024

It is difficult to study complex diseases because science is often limited to tightly-controlled environments – and animal models – that don’t always accurately reflect the real world. A capillary shrinks over time – it’s a temporal process – but science is often limited to static snapshots.

Science 76

Science Disease Research RNA 76

Broad Institute

JANUARY 8, 2024

Now the researchers describe how they re-engineered both eVLPs and parts of the prime editing protein and RNA machinery to boost editing efficiency up to 170 times in human cells compared to the previous eVLPs that deliver base editors. They also delivered prime editors to the mouse brain, and did not detect any off-target editing.

Engineering 144

Engineering Research Virus DNA 144

Sygnature Discovery

SEPTEMBER 11, 2024

We’ve successfully tackled targets for: Unprecedented membrane proteins Intrinsically disordered proteins Refolding from inclusion bodies Large protein complexes Labelled proteins for NMR studies RNA structures by crystallography Across our capabilities Protein Expression & Purification Vast diversity of proteins produced.

Science 52

Science Compound Screening RNA Protein Expression 52

Broad Institute

JUNE 28, 2023

Today, scientists use these reactions to produce customizable DNA and RNA molecules that enable genetic sequencing, drug and vaccine development, pathogen tests, cancer diagnostics, and many aspects of basic biomedical research. “I Longer synthetic DNA and RNA molecules are also critical for modern biologic drugs.

DNA 98

DNA RNA Science Therapies 98

Broad Institute

DECEMBER 6, 2023

Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. Tags: Cell Circuits Program Immunology RNA sequencing The reference, called the Immune Dictionary , appears today in Nature. Paper cited Cui A et al.

Immune Response 138

Immune Response RNA Disease Medical Schools 138