Broad Institute

JANUARY 30, 2024

More bottles on the medicine shelf would help, but Bhattacharyya, who’s now also a research scientist, realized that science might lead to better tools for diagnosing and treating such challenging cases. FROM STARS TO CELLS Bhattacharyya’s interest in science began not in the lab, but in the sky.

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Hospitals Medical Schools Virus Science 137

Codon

MARCH 20, 2023

Basic Science A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Science Advances. Science Advances. Ribozyme-mediated RNA synthesis and replication in a model Hadean microenvironment. Assembly of metabolons in yeast using Cas6-mediated RNA scaffolding.

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Virus Engineering RNA Small Molecule 52

Broad Institute

MAY 16, 2024

By Allessandra DiCorato May 16, 2024 Credit: Deverman lab Brain vasculature (in blue) surrounded by RNA (in orange) transcribed from the gene delivered to the brain in humanized mice using an engineered AAV targeting the human transferrin receptor. Paper cited Huang Q, Chan KY, et al. Online May 16, 2024. DOI: 10.1126/science.adm8386.

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Therapies FDA Approval Engineering Disease 137

Broad Institute

JUNE 27, 2024

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain. Credit: Neumann EN, Bertozzi TM, et al.

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Disease Therapies Engineering Clinical Trials 142

PLOS: DNA Science

OCTOBER 24, 2024

In those early days, politicians and government officials who’d never heard terms like “cytokine storm” and “RNA virus” were suddenly charged with explaining what was happening. “Do Your Own Research” Fuels Science Illiteracy COVID reawakened the mantra DYOR: do your own research.

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Science Research Vaccine Government 57

Broad Institute

DECEMBER 13, 2023

The studies are from groups at the Broad, Allen Institute for Brain Science, the Salk Institute for Biological Studies, and other institutions that are part of the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies ® Initiative, or The BRAIN Initiative — Cell Census Network ( BICCN ).

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Drug Target Review

SEPTEMBER 4, 2023

Infectious agent includes bacteria, virus, fungi, and parasites, and they are capable of causing disease in a living organism. I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. We discovered it is highly effective and environmentally friendly.

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Drugs RNA DNA Disease 111

Codon

DECEMBER 12, 2024

” The report accompanies an article in Science , also released today, entitled “Confronting Risks of Mirror Life.” For the article in Science , more than 30 scientists from ten countries are calling on the broader community to confront the risks of mirrored life. ” But what, exactly, is a mirrored organism?

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DNA RNA Vaccine Virus 81

PLOS: DNA Science

JUNE 13, 2024

Ruling Out Alternate Explanations Requires Logic and Science Soon after Fauci’s grilling, Alina Chan, a molecular biologist at the Broad Institute of MIT and Harvard, succinctly explained the converging evidence in a compelling Opinion piece in the June 9 New York Times. An altered virus could have escaped. Her points: 1.

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PLOS: DNA Science

JULY 27, 2023

The owners of the felines all reported feeding their pets raw meat, and samples of the meat revealed not only flu virus genetic material, but also infectious virus. The fear is that a variant of the deadly virus might emerge that infects people, and, worst-case-scenario, passes from person to person. emerged in late 2021.

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Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus. paper cited Wu M, Kondo H, et al. Online July 11, 2024.

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Treatment Immune Response Virus Drugs 72

PerkinElmer

JULY 13, 2020

The complex relationship between a virus and its host is one of the hottest topics in science right now, and has been given considerable attention in recent weeks as a result of the race to understand the virus that causes COVID-19 and its potential vulnerabilities.

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RNA Virus Laboratories Science 52

The Pharma Data

OCTOBER 21, 2020

The COVID-19 pandemic has highlighted the urgent need for a novel, oral antiviral to treat this highly infectious and often deadly virus,” said Jean-Pierre Sommadossi, Ph.D., “Roche shares our passion for delivering innovative new medicines to address great unmet medical needs. Chief Executive Officer and Founder of Atea Pharmaceuticals.

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RNA Pharmaceuticals Virus Small Molecule 52

Drug Target Review

SEPTEMBER 28, 2023

They had the science and the technology but not the business model. For security reasons, at the time COVID-19 had to be grown in BSL-3 labs, which can be dangerous because they were handling the live virus. These are synthetic, not the live virus, so do not pose a risk of infection. Twist was officially founded in 2013.

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DNA Organic Chemistry Science Virus 116

Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). While mRNA data was often illuminating, their interpretation was tricky; more akin to art than science. There was scFormer in 2022, scGPT in 2023, and plenty of others.

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Engineering Virus DNA Therapies 132

The Pharma Data

JULY 29, 2021

Gilead Sciences, Inc. Our flagship HIV therapy, Biktarvy, saw continued growth and gains in market share, despite the ongoing impact of the pandemic,” said Daniel O’Day, Chairman and Chief Executive Officer, Gilead Sciences. econd Quarter 2021 Product Sales Increased 21% Year-Over-Year Primarily Driven by Veklury. Viral Diseases.

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Science Production Treatment FDA 52

Drug Target Review

MARCH 21, 2024

Because mRNA is not a virus, it doesn’t have to meet biosafety requirements for manufacturing and administration that an AAV approach would need. Additionally, the COVID-19 RNA vaccines have already demonstrated how safe RNA can be, and we look forward to seeing additional safety data on RNA approaches as the field continues to grow.

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The Pharma Data

NOVEMBER 1, 2021

Rice University researchers have introduced an online portal to help researchers screen COVID-19 drug candidates that might attack specific proteins of the SARS-CoV-2 virus. Understanding these structures allows researchers to find binding partners that could, ideally, deactivate the virus.

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Virus RNA Engineering Drugs 52

The Pharma Data

JANUARY 31, 2021

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. FDA approval for prevention of infection caused by all known subtypes of hepatitis B virus in adults age 18 years and older. About GlaxoSmithKline.

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Clinical Trials Vaccine Trials Virus 52

The Pharma Data

DECEMBER 3, 2020

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. GSK is a science-led global healthcare company with a special purpose: to help people do more, feel better, live longer.

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Vaccine Immune Response Virus RNA 52

PerkinElmer

JULY 13, 2020

From this data, scientists have begun to try to classify different subtypes and create phylogenetic trees of the virus to understand how the viral genome is evolving as it spreads across the globe. The question as to whether these genome variations lead to different strains of the novel virus (i.e. Why and how do viruses evolve?

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Treatment DNA Virus RNA 52

The Pharma Data

OCTOBER 19, 2020

20, 2020 /PRNewswire/ — Caris Life Sciences® , a leading innovator in molecular science focused on fulfilling the promise of precision medicine, announced today that Winship Cancer Institute of Emory University (Winship) has joined Caris’ Precision Oncology Alliance (The Alliance/POA). . IRVING, Texas and ATLANTA , Oct.

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Clinical Trials RNA DNA Science 52

Broad Institute

AUGUST 11, 2022

The study appears in Science. Two viral proteins elicited an immune response: the portal, a part of the virus’s capsid shell, which contains viral DNA; and the terminase, the molecular motor that helps assemble the virus by pushing the viral DNA into the capsid. The cells underwent a dramatic defensive response and survived.

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DNA Virus Immune Response Bioinformatics 52

The Pharma Data

FEBRUARY 25, 2022

“There remains an urgent need for SARS-CoV-2 therapeutic agents that target parts of the virus other than the spike protein that are not as likely to evolve.” “In cell culture, we showed that if you combine Mpro and PLpro inhibitors, you have a stronger effect on the virus without increasing toxicity,” said Jose.

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FDA Approval Molecular Biology FDA Virus 52

NIH Director's Blog: Drug Development

NOVEMBER 16, 2021

The most recent exciting news started to roll out earlier this month when a Pfizer research team published in the journal Science some promising initial data involving the antiviral pill and its active compound [1]. The virus uses this enzyme to snip some longer viral proteins into shorter segments for use in replication.

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Clinical Trials Virus FDA Hospitals 52

The Pharma Data

JULY 6, 2021

But HIV’s ability to mutate isn’t unique among RNA viruses – most viruses develop mutations, or changes in their genetic code, over time. Changes in mutationally constrained epitopes are rare, as they can cause the virus to lose its ability to infect and replicate, essentially rendering it unable to propagate itself.

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Vaccine Virus Research Immune Response 52

Codon

APRIL 9, 2023

“Computer science is to biology what calculus is to physics.” Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. My goal is to reach 100 supporters!

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Therapies RNA Engineering Vaccine 52

The Pharma Data

MARCH 20, 2021

of Medicine and Health Sciences (Ghent University) and. Biogazelle, an innovative bioanalytical services company offering RNA and. Ghent University Hospital for SARS-CoV-2 virus screening. study RNA virus replication and virus-host interactions and in particular the use of single-cell proteomics to aid in this research.

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Laboratories Virus RNA Bioinformatics 52

Codon

APRIL 2, 2023

Basic Science *No evidence for a common blood microbiome based on a population study of 9,770 healthy humans. Read A new DNA polymerase variant, called RT-KTq I614Y, can directly detect RNA modifications, including pseudouridine (Ψ) and queuosine (Q). Massively parallel profiling of RNA-targeting CRISPR-Cas13d.

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DNA RNA Engineering Licensing 52

The Pharma Data

MARCH 9, 2022

Novartis today announced a license option agreement with Voyager Therapeutics, a gene therapy company focused on next-generation adeno-associated virus (AAV) technologies, for three capsids to use in potential gene therapies for neurological diseases, with options to access capsids for two other targets. About Novartis.

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Licensing Licensing Therapies Disease 52

The Pharma Data

SEPTEMBER 28, 2021

Respiratory infections are caused by a good sort of pathogens, like influenza viruses, respiratory syncytial virus, parainfluenza viruses, metapneumovirus, rhinovirus, enterovirus, coronavirus and adenovirus, and other bacteria pathogens.

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Marketing Virus DNA Disease 52

Codon

JUNE 25, 2024

Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. Proteins are colored blue and RNA molecules are colored orange and yellow. RNA and proteins comprise each ribosome, but the cell synthesizes these two biomolecules at different rates. The large and small ribosome subunits.

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The Pharma Data

JANUARY 21, 2021

This was the first-ever, pre-approval implementation science study developed to evaluate ways to integrate Cabenuva into U.S. While much more remains to be done to make HIV history, today’s milestone reminds us how far medical innovation has come since the first reported cases of the virus almost 40 years ago.”. clinical practices.

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FDA Approval Treatment FDA Clinical Trials 52

Codon

MAY 30, 2023

The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Science Advances.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Science Advances.

DNA 52

DNA RNA Engineering Vaccine 52

PerkinElmer

AUGUST 18, 2020

The time sensitivity of virus research, combined with an increasing complexity of bench tasks, can make it helpful for labs to increase automaticity of experiments. For this reason, it might be necessary for research teams to screen many potential leads before they find one or two with strong potential. Sources Zhang et al.

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Virus Vaccine RNA DNA 52

Codon

JULY 27, 2023

From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% in Science. Because it turns out that at least half of them , in humans, also bind to RNA molecules. How do transcription factors couple up with the correct RNA molecule? From Sulis D.B.

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Therapies RNA DNA Engineering 52