Codon

AUGUST 26, 2024

When COVID-19 emerged in 2019, by contrast, mRNA vaccines developed by Pfizer and Moderna took just 326 days from the initial sequencing of the virus to gaining approval for emergency use. These drugs would be ideal tools to bridge the wait for a vaccine against a quickly-spreading virus.

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RNA Virus DNA Vaccine 95

Drug Discovery World

MARCH 7, 2024

Ginkgo Bioworks has acquired Patch Biosciences, with the intention to strengthen its gene therapy services, cell therapy services, and RNA therapeutics services. The collaboration achieved its goals of enhancing the AAV production titres of Biogen’s gene therapy manufacturing processes.

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RNA Engineering Therapies Virus 130

Drug Discovery Today

MAY 10, 2021

A new approach to tackling viruses by targeting the ‘control centre’ in viral RNA could lead to broad spectrum anti-viral drugs and provide a first line of defence against future pandemics, according to new research at the University of Birmingham.

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RNA Virus Drugs Research 100

Drug Discovery World

AUGUST 20, 2024

The drug delivered a statistically significant increase in survival time when given at 150mg/kg twice a day (BID) in a United States Army Medical Research Institute of Infectious Diseases (USAMRIID) in vivo Ebola virus study, making it the first host-directed molecule to show activity in Ebola virus disease.

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Treatment Virus RNA Therapies 148

Drug Discovery World

MARCH 26, 2024

Additional approaches, such as profiling of RNA and proteins, and the use of artificial intelligence (AI), could be key to providing a more comprehensive picture of a patient’s tumour and enable the use of optimised treatments. MT: Why was STORM attending the conference?

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Drug Discovery World

JUNE 20, 2024

RNA sequencing and B cell receptor analyses showed that conventional dendritic cells and canonical monocytes exhibited attenuated IFN signalling for patients in which auto-antibodies were present. Interestingly, there were no characteristic clinical features among patients with auto-antibodies to t1-IFNs,” commented Dr Iwamura.

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Immune Response Virus RNA Research 148

Broad Institute

JUNE 18, 2024

Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus.

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Virus RNA Medical Schools Laboratories 144

Drug Discovery World

JANUARY 27, 2023

EMA prioritises AAV gene therapy for Krabbe disease The European Medicines Agency (EMA) has granted priority medicines (PRIME) designation to FBX-101, Forge Biologic’s adeno-associated virus (AAV) drug candidate for treating patients with Krabbe disease.

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RNA Therapies Drugs Virus 130

Drug Discovery World

OCTOBER 24, 2022

New research suggests messenger RNA can be effectively used as a ‘universal’ therapy against different coronaviruses. . Rather than messenger RNA as a vaccine, this shows that mRNA can be used as a universal therapy against different coronaviruses,” said Gaurav Sahay, OSU and the Texas Biomedical Research Institute.

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Treatment RNA Protein Production Virus 100

Drug Discovery World

JULY 19, 2022

An early-stage clinical trial has been launched in the US investigating a vaccine against Nipah virus infection. . The clinical trial has been launched by the National Institute of Allergy and Infectious Diseases (NIAID) to evaluate an investigational vaccine to prevent infection with Nipah virus. Official comments . Fauci, M.D.

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Clinical Trials Trials Virus Vaccine 130

Drug Discovery World

MAY 17, 2024

Data demonstrates superiority of circular RNA vs linear mRNA In vivo proof-of-concept for Circio Holding’s differentiated circVec platform approach to gene therapy has been demonstrated in two posters at the American Society of Gene & Cell Therapy (ASGCT) 2024 annual meeting.

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Therapies Vaccine RNA Clinical Trials 130

The Pharma Data

MARCH 23, 2022

To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase. Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives.

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Virus Small Molecule Protein Production Research 52

Drug Discovery World

JANUARY 11, 2024

Researchers have used messenger RNA (mRNA) to create an effective therapy for a rare liver disease in preclinical studies, demonstrating the technology’s potential therapeutic use in people. Patients affected by the disease are found to also experience an imbalance of glutathione regulation, which is important for liver detoxification.

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Disease Research RNA Therapies 148

Drug Discovery World

MAY 22, 2023

Cell therapy, RNA technology, antibody drug conjugates and AI/machine learning are among the key areas of investment for pharma, according to a new report. Pharma is also keen to access next generation RNA platforms, such as self-amplifying RNAs derived from the genomes of positive-strand RNA viruses.

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Pharma Companies RNA Therapies Virus 130

Drug Discovery World

MAY 13, 2024

MA: Regarding vaccine development specifically, and the role my team plays in the development of cryogenic electron microscopy (cryo-EM) technology, we see the study and dissemination of virus structures, and the proteins that comprise them, as vital to vaccine design. RA: How reliable are vaccines now for respiratory viruses such as flu?

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Vaccine Virus Small Molecule Disease 148

Drug Discovery World

JUNE 22, 2023

The technology enables active loading of adeno-associated virus (AAV) into exosomes followed by their release when the AAV-loaded exosomes are delivered into recipient cells. This is part of our long-term business strategy of leveraging exosome-mediated delivery to create and enable genetic medicines such as gene therapy and genome editors”.

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RNA Engineering Virus Therapies 130

PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. An altered virus could have escaped. Evidence that the virus emerged, or escaped, from the wildlife trade is lacking. Her points: 1. Coincidence? I’ve never thought so. RaTG13 shares about 96.1%

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Virus RNA DNA Science 52

Chemical Biology and Drug Design

NOVEMBER 13, 2023

WHO proclaimed the outbreak of the Ebola virus disease (EVD), in 2014 that killed hundreds of people in West Africa. The development of vaccines for SARS-CoV-2 becomes more difficult due to the viral mutation in its non-structural proteins (NSPs) especially NSP2 and NSP3, S protein, and RNA-dependent RNA polymerase (RdRp).

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Vaccine Laboratories RNA Virus 100

Drug Discovery World

JUNE 14, 2023

An FDA approval for Pfizer’s Abrysvo respiratory syncytial virus (RSV) vaccine is likely to threaten GSK’s current hold on the market, according to GlobalData. As an RNA virus, RSV is capable of rapid mutation to escape attack by new pharmaceuticals.

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Vaccine Virus FDA FDA Approval 130

Drug Discovery World

JANUARY 17, 2023

Oregon State University College of Pharmacy scientists have shown that lipid nanoparticles and messenger RNA could treat blindness associated with a rare genetic condition. . The research aims to develop solutions for the limitations associated with adeno-associated virus (AAV), the current primary means of delivery for gene editing. .

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Small Molecule Pharmacy RNA Packaging 246

Chemical Biology and Drug Design

JULY 27, 2023

cells induced by poly (I:C) were treated with or without PA, and then RNA-sequencing, GO and KEGG analysis were carried out to obtain the five differentially expressed genes (IL-1β, HMOX1, PTGS2, Abca1, and P65), which were verified by QRT-PCR and western blot. RNA-sequencing was applied to analyze the differentially expressed genes (DEGs).

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RNA Virus Disease Drugs 100

Drug Discovery World

NOVEMBER 1, 2022

He published ‘maps” depicting how various cell types use alternative splicing of messenger RNA to construct genetic templates that produce an ever-changing set of proteins in the cell. . The SLED package released RNA-producing protein that made the melanoma cells die. . Dubbed ‘splicing-linked expression design’ (SLED). .

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Packaging RNA Laboratories Therapies 130

Drug Discovery World

MAY 18, 2023

Moreover, some strains of influenza virus have significant pandemic potential. While one portion of the HA protein, known as the head, tends to change as the flu virus spreads and evolves, a more stable portion, known as the stem, evolves very slowly and is very similar across many different types of the flu virus.

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Clinical Trials Vaccine Trials Immune Response 130

Drug Discovery World

MAY 23, 2024

Reece Armstrong speaks to Samuel Deutsch , Chief Scientific Officer of Nutcracker Therapeutics about the RNA landscape and how it can benefit the development of immunotherapies. RA: What role does RNA play in the development of effective immunotherapies? RA: What lessons for RNA development did we learn from the Covid-19 pandemic?

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RNA Therapies Engineering Disease 148

Drug Discovery World

OCTOBER 31, 2022

Separately, UCSF QBI and the Institut Pasteur will jointly establish the Institut Pasteur-UCSF QBI Center of Excellence in Emerging Infectious Diseases with planned operations in San Francisco and Paris. .

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Research RNA International Virus 130

Drug Discovery World

JULY 8, 2024

Beard Distinguished Professor of Experimental Surgery and the Founding Director of the Translational Research Institute at Duke University, explores the rise of RNA therapeutics. However, the RNA landscape has drastically changed in recent years and we now know that the molecule is more than just a transient, linear carrier of information.

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RNA Small Molecule Vaccine FDA Approval 148

Drug Target Review

JUNE 28, 2023

Using a synthetic guide RNA (gRNA), scientists can target a specific DNA sequence and employ Cas9 to cut it. Clustered regularly interspaced short palindromic repeats (CRISPR) was first discovered in the genome of marine bacteria. This allowed bacteria to recognise subsequent attacks and cleave the viral DNA to stop the viral infection.

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Engineering DNA Immune Response RNA 98

The Pharma Data

AUGUST 16, 2021

The antiviral agent incorporates RNA-like building blocks into the RNA genome of the virus. If this genetic material is further replicated, defective RNA copies are produced and the pathogen can no longer spread. ” Mutations in the genome stop the virus.

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RNA Virus Clinical Trials Drugs 52

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. The novel, hairpin-shaped molecule was named cabRNA for CBASS-activating bacteriophage RNA.

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RNA Immune Response DNA Molecular Biology 59

ASPET

JULY 19, 2023

Ras- G TPase-activating protein (SH 3 domain)- b inding p roteins (G3BP) are RNA binding proteins that plays a critical role in stress granule (SG) formation. Recent evidence suggests that G3BPs can also regulate mRNA expression through interactions with RNA outside of SGs.

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RNA Virus Regulations Disease 40

Covalent Modifiers

DECEMBER 23, 2023

3c10581 Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived from ATP hydrolysis to remodel DNA and RNA substrates. Kapoor Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.3c10581 Therefore, helicases are important targets for chemical probes and therapeutics.

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RNA DNA Virus 77

Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus.

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Treatment Immune Response Virus Drugs 72

Drug Target Review

FEBRUARY 7, 2024

For example, innate immune peptides being imitated by SARS-CoV-2 fragments have a special ability to organise double stranded RNA into structures that strongly amplify activation of the human innate immune system in autoimmune diseases. Maybe the next pandemic respiratory virus will be an influenza virus rather than a coronavirus.

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RNA Virus Immune Response Engineering 69

Broad Institute

AUGUST 31, 2023

Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses. In the past, Broad researchers have optimized the pegRNA and the way the cell responds to prime editing to boost editing efficiency.

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DNA Engineering RNA Laboratories 145

The Pharma Data

JANUARY 21, 2021

President Joe Biden has promised to re-energize the nation’s response to COVID-19, but one of his top pandemic advisors says that effort could be hamstrung by both the virus and the failings of the previous administration. People also haven’t been provided clear messaging on the messenger RNA vaccines, Osterholm added.

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Vaccine Virus RNA Research 52

The Pharma Data

JANUARY 10, 2021

The VIR Seek SARS-CoV-2 Solution is a comprehensive workflow for the detection of SARS-CoV-2 on environmental surfaces that includes swabbing of environmental surfaces, RNA extraction, analysis by Reverse Transcription PCR (RT-PCR) and evaluation by an advanced algorithm.

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RNA Virus Research 52

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

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Therapies RNA Protein Expression DNA 59