Science Daily: Pharmacology News

DECEMBER 2, 2024

Results bring science one step closer to automating one of the most widely used methods in genomics research. New research suggests that large language models like GPT-4 could streamline the process of gene set enrichment, an approach what genes do and how they interact.

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Drug Target Review

DECEMBER 20, 2024

Smith identifies three key obstacles preventing broader acceptance of AI: Communication gaps : Pharmaceutical and computational science communities often struggle to understand each others technical languages, making collaboration difficult.

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Clinical Trials Trials Pharmaceuticals Drug Development 128

DrugBaron

FEBRUARY 16, 2024

And today it has earned its place in the lexicon of life science venture capital, playing a key role in generating returns of investment houses across the globe. But it is not universal.

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Drug Development Pharma Companies Drugs Science 355

Drug Patent Watch

DECEMBER 10, 2024

Access to Advanced Science and Expertise : Embedded CDMOs, which are part of larger pharmaceutical companies, can offer access to world-class science, chemistry, and people, as well as advanced facilities and sustained investment in innovation.

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Drug Development Compliance Pharmaceutical Companies Drugs 96

Drug Target Review

DECEMBER 9, 2024

the life sciences and pharmaceutical industries increasingly rely on AI-driven discoveries, companies operating in this space will need to carefully consider how to obtain meaningful protection for both the AI platforms and the products generated by such platforms.

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Engineering International Drug Development Science 105

Broad Institute

JANUARY 9, 2025

In the future, they hope their methods may also help scientists design delivery vehicles to evade the immune system.

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Engineering Immune Response Therapies DNA 140

Drug Target Review

JANUARY 14, 2025

About the authors Dr Raminderpal Singh Dr Raminderpal Singh is a recognised visionary in the implementation of AI across technology and science-focused industries. For more insights, refer to Part 1 of this series, where we explore foundational concepts for early drug discovery workflows.

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Drugs Protein Expression Science Research 69

Drug Patent Watch

DECEMBER 9, 2024

In the vast realm of pharmaceutical research and development, there’s a fascinating intersection between ancient wisdom and modern science. “Pharmacognosy is the bridge between traditional medicine and modern pharmaceutical science, offering a treasure trove of potential new drugs waiting to be discovered.”

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Drugs Drug Development Pharmaceuticals Production 97

Practical Cheminformatics

OCTOBER 8, 2024

Some Parting Thoughts on LLMs for Science Over the last year, there has been tremendous hype around applying LLMs in science. LLMs for science are still in their infancy, and the field is progressing rapidly. Of course, this is ridiculous.

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Fragment Screening Packaging Organic Chemistry Small Molecule 136

Broad Institute

SEPTEMBER 23, 2024

Scolnick Professorship, Ono Pharma Breakthrough Science Initiative Award, Merkin Institute Fellowship, Klarman Cell Observatory, and a National Institutes of Health New Innovator Award. “Such a tiny chemical change can contribute such an amazing increase to mRNA stability and translatability.” and Virginia W. Cabot Professorship, E.

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RNA Vaccine Small Molecule Therapies 134

Broad Institute

OCTOBER 23, 2024

The DNA change underlying Emma’s disorder is now known, thanks to years of work by an international team of scientists and physicians at the Broad Institute of MIT and Harvard, Northwestern University, University of Nantes, the Weizmann Institute of Science, and the Baylor College of Medicine.

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DNA RNA Disease Hospitals 128

Codon

SEPTEMBER 29, 2024

While mRNA data was often illuminating, their interpretation was tricky; more akin to art than science. Models of life became the dominant research paradigm in nearly every life-sciences field. In short, the problem given to the model could be phrased as the following: given 19,980 mRNA values, predict values for the missing 20.

Engineering 134

Engineering Virus DNA Therapies 134

Drug Target Review

OCTOBER 30, 2024

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. 2017;23(1):49-59. Assembling human brain organoids. 2019;363(6423):126-7. Bleijs M, van de Wetering M, Clevers H, Drost J. Xenograft and organoid model systems in cancer research. 2019;38(15):e101654. Drost J, Clevers H. 2018;359(6378):920-6.

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Treatment Disease Clinical Trials Molecular Biology 105

Broad Institute

DECEMBER 11, 2024

Did that experience affect how you do science? We learned a lot about how to build community, and that's something I really value and I've been able to bring into my work and into every space that I am in. I found that there are a lot of ways that we can go into research thinking community first.

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Research DNA Clinical Research Science 105

Nvidia Developer: Drug Discovery

JANUARY 13, 2025

Traditional computational drug discovery relies almost exclusively on highly task-specific computational models for hit identification and lead optimization. Traditional computational drug discovery relies almost exclusively on highly task-specific computational models for hit identification and lead optimization.

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Drugs Research Science 136

Nvidia Developer: Drug Discovery

OCTOBER 2, 2024

A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options.

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Disease Doctors Drugs Treatment 140

Nvidia Developer: Drug Discovery

DECEMBER 3, 2024

Antibodies have become the most prevalent class of therapeutics, primarily due to their ability to target specific antigens, enabling them to treat a wide range.

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Small Molecule Disease Drugs Science 126

Drug Target Review

DECEMBER 4, 2024

G protein-coupled receptors (GPCRs) represent a cornerstone of modern drug discovery due to their crucial role in regulating human physiology and their involvement in numerous diseases. Many of these receptors are key targets for addressing obesity and metabolic disorders.

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Pharmacokinetics Small Molecule Therapies Immune Response 122

Science Daily: Pharmacology News

JANUARY 16, 2025

Increasingly common since 1980, persistent multi-year droughts will continue to advance with the warming climate, warns a new study. This publicly available forty-year global quantitative inventory seeks to inform policy regarding the environmental impact of human-induced climate change. It also detected previously 'overlooked' events.

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Science Daily: Pharmacology News

JANUARY 9, 2025

Construction materials such as concrete and plastic have the potential to lock away billions of tons of carbon dioxide, according to a new study by civil engineers and earth systems scientists.

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Engineering 145

Science Daily: Pharmacology News

JANUARY 15, 2025

The Atlantic Meridional Overturning Circulation (AMOC) has not slowed down since the mid-20th century based on the North Atlantic air-sea heat fluxes over that time.

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Science Daily: Pharmacology News

JANUARY 13, 2025

Researchers have developed a drastically smaller and more energy efficient method of creating coveted photon pairs that influence each other from any distance. The technology could transform computing, telecommunications, and sensing.

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Engineering Research 137

Science Daily: Pharmacology News

JANUARY 1, 2025

Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans -- including those causing flu, COVID, whooping cough and tuberculosis.

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Virus Disease Research 142

Science Daily: Pharmacology News

DECEMBER 25, 2024

Scientists have developed an innovative therapeutic platform by mimicking the intricate structures of viruses using artificial intelligence (AI).

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Virus 135

Science Daily: Pharmacology News

JANUARY 15, 2025

New proteins not found in nature have now been designed to counteract certain highly poisonous components of snake venom. The deep learning, computational methods for developing these toxin-neutralizing proteins offer hope for creating safer, more cost-effective and more readily available therapeutics than those currently in use.

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Science Daily: Pharmacology News

JANUARY 2, 2025

A research team has developed a method for extracting gold from electronics waste, then using the recovered precious metal as a catalyst for converting carbon dioxide (CO2), a greenhouse gas, to organic materials.

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Research 135

Science Daily: Pharmacology News

JANUARY 3, 2025

Scientists recently discovered that the giant 'conveyer belt' currents that push star-forged material out of our galaxy and pull it back in can also transport carbon atoms. That means that a good deal of the carbon here on Earth, including the carbon in our bodies, likely left the galaxy at some point!

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Science Daily: Pharmacology News

JANUARY 2, 2025

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

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Therapies Research 118

Science Daily: Pharmacology News

JANUARY 3, 2025

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.

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Disease Research 131

Science Daily: Pharmacology News

JANUARY 1, 2025

Waves of human migration across Europe during the first millennium AD have been revealed using a more precise method of analysing ancestry with ancient DNA, in research led by the Francis Crick Institute.

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DNA Research 131

Science Daily: Pharmacology News

JANUARY 3, 2025

Bioengineers have developed a new construction kit for building custom sense-and-respond circuits in human cells. The research could revolutionize therapies for complex conditions like autoimmune disease and cancer.

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Therapies Disease Research 130

Science Daily: Pharmacology News

JANUARY 13, 2025

A new study shows that the risk of developing dementia anytime after age 55 among Americans is 42%, more than double the risk reported by older studies.

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Science Daily: Pharmacology News

JANUARY 8, 2025

A good night's sleep does more than just help you feel rested--it might literally clear your mind. A new study shows how deep sleep may wash away waste buildup in the brain during waking hours, an essential process for maintaining brain health.

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Science Daily: Pharmacology News

AUGUST 5, 2024

Seeds, twigs, and insect parts found under two miles of ice confirm Greenland's ice sheet melted in the recent past, the first direct evidence that the center -- not just the edges -- of the two-mile-deep ice melted away in the recent geological past.

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Research 145

Science Daily: Pharmacology News

NOVEMBER 16, 2024

The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.

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Science Daily: Pharmacology News

AUGUST 13, 2024

Linked to cardiovascular and respiratory diseases in people, nanoplastics continue to build up, largely unnoticed, in the world's bodies of water. The challenge remains to develop a cost-effective solution to get rid of nanoplastics while leaving clean water behind. That's where Mizzou comes in.

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Disease Research 145

Science Daily: Pharmacology News

JANUARY 10, 2025

A new study has found that the composition of your gut microbiome helps predict how likely you are to succumb to potentially life-threatening infection with Klebsiella pneumoniae, E.coli and other bugs -- and it may be altered by changing your diet.

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