Drug Target Review

DECEMBER 9, 2024

the life sciences and pharmaceutical industries increasingly rely on AI-driven discoveries, companies operating in this space will need to carefully consider how to obtain meaningful protection for both the AI platforms and the products generated by such platforms.

Engineering 105

Engineering International Drug Development Science 105

Drug Patent Watch

DECEMBER 9, 2024

In the vast realm of pharmaceutical research and development, there’s a fascinating intersection between ancient wisdom and modern science. “Pharmacognosy is the bridge between traditional medicine and modern pharmaceutical science, offering a treasure trove of potential new drugs waiting to be discovered.”

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Drugs Drug Development Pharmaceuticals Production 87

Broad Institute

OCTOBER 28, 2024

To speed up the annotation step, the Broad Institute’s Data Sciences Platform (DSP) has developed a new search engine that automates much of this process by using machine learning to search data on more than 50 million annotated single cells. Tags: Data Sciences Platform Machine Learning Single Cell

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Engineering Cell Biology Disease RNA 119

Practical Cheminformatics

OCTOBER 8, 2024

Some Parting Thoughts on LLMs for Science Over the last year, there has been tremendous hype around applying LLMs in science. LLMs for science are still in their infancy, and the field is progressing rapidly. Of course, this is ridiculous.

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Fragment Screening Packaging Organic Chemistry Small Molecule 136

Broad Institute

SEPTEMBER 23, 2024

Scolnick Professorship, Ono Pharma Breakthrough Science Initiative Award, Merkin Institute Fellowship, Klarman Cell Observatory, and a National Institutes of Health New Innovator Award. “Such a tiny chemical change can contribute such an amazing increase to mRNA stability and translatability.” and Virginia W. Cabot Professorship, E.

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RNA Vaccine Small Molecule Therapies 133

Broad Institute

OCTOBER 23, 2024

The DNA change underlying Emma’s disorder is now known, thanks to years of work by an international team of scientists and physicians at the Broad Institute of MIT and Harvard, Northwestern University, University of Nantes, the Weizmann Institute of Science, and the Baylor College of Medicine.

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DNA RNA Disease Hospitals 128

Codon

SEPTEMBER 29, 2024

While mRNA data was often illuminating, their interpretation was tricky; more akin to art than science. Models of life became the dominant research paradigm in nearly every life-sciences field. In short, the problem given to the model could be phrased as the following: given 19,980 mRNA values, predict values for the missing 20.

Engineering 132

Engineering Virus DNA Therapies 132

Drug Target Review

OCTOBER 30, 2024

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. 2017;23(1):49-59. Assembling human brain organoids. 2019;363(6423):126-7. Bleijs M, van de Wetering M, Clevers H, Drost J. Xenograft and organoid model systems in cancer research. 2019;38(15):e101654. Drost J, Clevers H. 2018;359(6378):920-6.

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Treatment Disease Clinical Trials Molecular Biology 105

Nvidia Developer: Drug Discovery

OCTOBER 2, 2024

A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options.

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Disease Doctors Drugs Treatment 145

Drug Patent Watch

DECEMBER 10, 2024

Biotechnology and gene editing: Advances in biotechnology, particularly in areas like CRISPR gene editing, may create new patent thicket challenges in the life sciences sector. Internet of Things (IoT): The interconnected nature of IoT devices may lead to more complex patent thickets spanning multiple industries.

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Licensing Licensing International Marketing 98

Nvidia Developer: Drug Discovery

OCTOBER 23, 2024

Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer. Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery.

Engineering 124

Engineering Drugs Pharmaceuticals Research 124

Science Daily: Pharmacology News

DECEMBER 4, 2024

A new study sheds light on how long humans in the Americas have had relationships with the ancestors of today's dogs -- and asks an 'existential question': What is a dog?

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Science Daily: Pharmacology News

NOVEMBER 26, 2024

A striking new phenomenon is emerging: distinct regions are seeing repeated heat waves that are so extreme, they fall far beyond what any model of global warming can predict or explain. A new study provides the first worldwide map of such regions, which show up on every continent except Antarctica like giant, angry skin blotches.

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Science Daily: Pharmacology News

NOVEMBER 27, 2024

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.

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DNA Virus Treatment Research 124

Science Daily: Pharmacology News

DECEMBER 4, 2024

Exposure to car exhaust from leaded gas during childhood altered the balance of mental health in the U.S. population, making generations of Americans more depressed, anxious and inattentive or hyperactive, according to researchers.

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Research 132

Science Daily: Pharmacology News

DECEMBER 2, 2024

Researchers have linked a specific type of body fat to the abnormal proteins in the brain that are hallmarks of Alzheimer's disease up to 20 years before the earliest symptoms of dementia appear, according to a new study.

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Disease Research 132

Science Daily: Pharmacology News

NOVEMBER 22, 2024

New research has uncovered what may be the oldest direct evidence of ancient hot water activity on Mars, revealing the planet may have been habitable at some point in its past.

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Research 132

Science Daily: Pharmacology News

NOVEMBER 16, 2024

The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.

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Science Daily: Pharmacology News

AUGUST 13, 2024

Linked to cardiovascular and respiratory diseases in people, nanoplastics continue to build up, largely unnoticed, in the world's bodies of water. The challenge remains to develop a cost-effective solution to get rid of nanoplastics while leaving clean water behind. That's where Mizzou comes in.

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Disease Research 145

Science Daily: Pharmacology News

NOVEMBER 27, 2024

Recent results from a recent clinical trial indicate that a twice-yearly injection of Lenacapavir offers an overall 96% reduced risk of acquiring HIV. This makes Lenacapavir significantly more effective than the standard daily oral PrEP (pre-exposure prophylaxis).

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Clinical Trials Trials 127

Science Daily: Pharmacology News

SEPTEMBER 17, 2024

Consuming moderate amounts of coffee and caffeine regularly may offer a protective effect against developing multiple cardiometabolic diseases, including type 2 diabetes, coronary heart disease and stroke, according to new research.

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Disease Research 145

Science Daily: Pharmacology News

AUGUST 23, 2024

A study found that nondeceptive placebos, or placebos given with people fully knowing they are placebos, effectively manage stress -- even when the placebos are administered remotely.

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Science Daily: Pharmacology News

SEPTEMBER 9, 2024

Scientists have developed a new AI algorithm that can separate brain patterns related to a particular behavior. This work promises to improve brain-computer interfaces and aid with the discovery of new brain patterns.

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Science Daily: Pharmacology News

AUGUST 14, 2024

A new brain-computer interface translates brain signals into speech with up to 97 percent accuracy. Researchers implanted sensors in the brain of a man with severely impaired speech due to amyotrophic lateral sclerosis (ALS). The man was able to communicate his intended speech within minutes of activating the system.

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Research 144

Science Daily: Pharmacology News

AUGUST 22, 2024

Non-living hydrogels can play the video game Pong and improve their gameplay with more experience, researchers report.

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Research 144

Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Researchers have created microscale robots less than 1 millimeter in size that are printed as a 2D hexagonal 'metasheet' but, with a jolt of electricity, morph into preprogrammed 3D shapes and crawl.

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Research 144

Science Daily: Pharmacology News

AUGUST 9, 2024

A 'loopy' discovery in bacteria is raising fundamental questions about the makeup of our own genome -- and revealing a potential wellspring of material for new genetic therapies.

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Therapies 143

Science Daily: Pharmacology News

OCTOBER 3, 2024

Comamonadacae is a family of bacteria often found growing on plastics in water. New study finds a bacterium in this family can break down the plastic for food. Researchers also identified the enzyme the bacterium use to degrade plastic.

Engineering 143

Engineering Research 143

Science Daily: Pharmacology News

OCTOBER 10, 2024

Researchers developed a rating system to evaluate the plausibility of climate model simulations in the IPCC's latest report, and show that models that lead to potentially catastrophic warming are to be taken seriously.

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Research 143

Science Daily: Pharmacology News

OCTOBER 17, 2024

A major new study reveals that carbon dioxide emissions from forest fires have surged by 60 percent globally since 2001, and almost tripled in some of the most climate-sensitive northern boreal forests.

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Science Daily: Pharmacology News

OCTOBER 22, 2024

Polar bears in some parts of the high Arctic are developing ice buildup and related injuries to their feet. The changes appear to be an unexpected consequence of climate change, related to changing conditions in a warming Arctic.

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Science Daily: Pharmacology News

DECEMBER 4, 2024

Some people bounce back from trauma, but others get caught in depressive loops that sap the joy from their lives.

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Science Daily: Pharmacology News

NOVEMBER 27, 2024

A recent trial finds an injection given during some asthma and COPD attacks is more effective than the current treatment of steroid tablets, reducing the need for further treatment by 30%.

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Treatment Trials 124

Science Daily: Pharmacology News

AUGUST 22, 2024

A new study finds that mitochondria in our brain cells frequently fling their DNA into the cells' nucleus, where the mitochondrial DNA integrates into chromosomes, possibly causing harm.

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DNA 141

Science Daily: Pharmacology News

NOVEMBER 25, 2024

A new computer model can be used to detect and measure interior oceans on the ice covered moons of Uranus. The model works by analyzing orbital wobbles that would be visible from a passing spacecraft. The research gives engineers and scientists a slide-rule to help them design NASA's upcoming Uranus Orbiter and Probe mission.

Engineering 124

Engineering Research 124

Science Daily: Pharmacology News

NOVEMBER 26, 2024

Researchers have made a record-breaking astrophysical discovery while simultaneously uncovering a possible explanation for the rare and extreme astrophysical event known as long-period radio transients.

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Research 124

Science Daily: Pharmacology News

DECEMBER 3, 2024

An average of four minutes of incidental vigorous physical activity a day could almost halve the risk of major cardiovascular events, such as heart attacks, for middle-aged women who do not engage in structured exercise, according to new research.

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Research 124