Overcoming Barriers to Generative AI in Life Sciences R&D
Fierce BioTech
OCTOBER 30, 2024
| While artificial intelligence is on everyone’s minds and in many R&D plans, adoption of generative AI has been slow so far in life sciences.
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Pioneer Group’s life sciences campuses host biggest Ada Lovelace Day event to date
Drug Discovery Today
OCTOBER 15, 2024
Pioneer Group, the specialist life science infrastructure and venture-building company, welcomed 425 school children from 29 schools to eight of its sites across the UK last week to mark Ada Lovelace Day, an international celebration of the achievements of women in STEM.
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Science Reveals Why Cancer Immunotherapies Can Sometimes Harm the Heart
Drugs.com
NOVEMBER 8, 2024
FRIDAY, Nov. 8, 2024 -- Researchers think they’ve figured out why cancer treatments that harness a person’s immune system to fight a tumor can cause heart damage in rare instances.Further, what they’ve learned sheds light on how this potentially dea.
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Arch raises another $3B biotech fund in pursuit of ‘coolest’ new science
BioPharma Drive: Drug Pricing
SEPTEMBER 26, 2024
Despite working in a restrictive funding climate, the prolific startup creator is “in the ‘taking lots of risk’ mode,” said co-founder and managing director Robert Nelsen.
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Boost Alphafold2 Protein Structure Prediction with GPU-Accelerated MMseqs2
Nvidia Developer: Drug Discovery
NOVEMBER 13, 2024
The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. This is often done in the form of a.
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An Alzheimer’s drugmaker is accused of data manipulation. Should its trials be stopped?
BioPharma Drive: Drug Pricing
OCTOBER 4, 2024
An experimental Alzheimer’s therapy from Cassava Sciences is still being tested in two Phase 3 studies, even as the company has come under regulatory scrutiny.
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RNA editing: emerging from CRISPR’s shadow
BioPharma Drive: Drug Pricing
OCTOBER 22, 2024
Early study data from Wave Life Sciences suggests how editing RNA may yield viable medicines. Large and small drugmakers say such results are just the start.
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How artificial intelligence could automate genomics research
Science Daily: Pharmacology News
DECEMBER 2, 2024
Results bring science one step closer to automating one of the most widely used methods in genomics research. New research suggests that large language models like GPT-4 could streamline the process of gene set enrichment, an approach what genes do and how they interact.
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How AI will reshape pharma by 2025
Drug Target Review
DECEMBER 20, 2024
Smith identifies three key obstacles preventing broader acceptance of AI: Communication gaps : Pharmaceutical and computational science communities often struggle to understand each others technical languages, making collaboration difficult.
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A therapy candidate for fatal prion diseases turns off disease-causing gene
Broad Institute
JUNE 27, 2024
Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain. Credit: Neumann EN, Bertozzi TM, et al.
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Lessons from Monte Carlo Models: Why Drug Development is Hard
DrugBaron
FEBRUARY 16, 2024
And today it has earned its place in the lexicon of life science venture capital, playing a key role in generating returns of investment houses across the globe. But it is not universal.
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Nobel Prize celebrates AI’s role in protein structure innovation
Drug Target Review
DECEMBER 9, 2024
the life sciences and pharmaceutical industries increasingly rely on AI-driven discoveries, companies operating in this space will need to carefully consider how to obtain meaningful protection for both the AI platforms and the products generated by such platforms.
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Pharmacognosy and Drug Patents: Unveiling Nature’s Medicinal Treasures
Drug Patent Watch
DECEMBER 9, 2024
In the vast realm of pharmaceutical research and development, there’s a fascinating intersection between ancient wisdom and modern science. “Pharmacognosy is the bridge between traditional medicine and modern pharmaceutical science, offering a treasure trove of potential new drugs waiting to be discovered.”
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New machine learning-based single-cell search engine makes cell annotation faster, more efficient
Broad Institute
OCTOBER 28, 2024
To speed up the annotation step, the Broad Institute’s Data Sciences Platform (DSP) has developed a new search engine that automates much of this process by using machine learning to search data on more than 50 million annotated single cells. Tags: Data Sciences Platform Machine Learning Single Cell
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Silly Things Large Language Models Do With Molecules
Practical Cheminformatics
OCTOBER 8, 2024
Some Parting Thoughts on LLMs for Science Over the last year, there has been tremendous hype around applying LLMs in science. LLMs for science are still in their infancy, and the field is progressing rapidly. Of course, this is ridiculous.
The Dangers of Mirrored Life
Codon
DECEMBER 12, 2024
” The report accompanies an article in Science , also released today, entitled “Confronting Risks of Mirror Life.” For the article in Science , more than 30 scientists from ten countries are calling on the broader community to confront the risks of mirrored life. ” But what, exactly, is a mirrored organism?
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ChEMBL brings drug bioactivity data to the Protein Data Bank in Europe
The ChEMBL-og
OCTOBER 23, 2024
This will ultimately accelerate research in diverse fields, including drug discovery materials science, and advance our understanding of fundamental biological processes. BioChemGraph’s training material is now available! -> > BCG Training More information can be found in the official EBI communications article.
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The Role of Scientific Expertise in Generic Drug Development
Drug Patent Watch
DECEMBER 10, 2024
The Science Behind Generic Drug Development. C., & Kern, S. Scientific Considerations for Global Drug Development. Retrieved from [link] East Street Pharmacy. Retrieved from [link] Source
New approach may yield modified messenger RNAs for treating a wide range of conditions
Broad Institute
SEPTEMBER 23, 2024
Scolnick Professorship, Ono Pharma Breakthrough Science Initiative Award, Merkin Institute Fellowship, Klarman Cell Observatory, and a National Institutes of Health New Innovator Award. “Such a tiny chemical change can contribute such an amazing increase to mRNA stability and translatability.” and Virginia W. Cabot Professorship, E.
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To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives
Broad Institute
OCTOBER 23, 2024
The DNA change underlying Emma’s disorder is now known, thanks to years of work by an international team of scientists and physicians at the Broad Institute of MIT and Harvard, Northwestern University, University of Nantes, the Weizmann Institute of Science, and the Baylor College of Medicine.
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Models of Life
Codon
SEPTEMBER 29, 2024
While mRNA data was often illuminating, their interpretation was tricky; more akin to art than science. Models of life became the dominant research paradigm in nearly every life-sciences field. In short, the problem given to the model could be phrased as the following: given 19,980 mRNA values, predict values for the missing 20.
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Organoids: the versatile platform for discovery and regeneration
Drug Target Review
OCTOBER 30, 2024
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. 2017;23(1):49-59. Assembling human brain organoids. 2019;363(6423):126-7. Bleijs M, van de Wetering M, Clevers H, Drost J. Xenograft and organoid model systems in cancer research. 2019;38(15):e101654. Drost J, Clevers H. 2018;359(6378):920-6.
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#WhyIScience Q&A: A computational biologist’s world travels have shaped her approach to research
Broad Institute
DECEMBER 11, 2024
Did that experience affect how you do science? We learned a lot about how to build community, and that's something I really value and I've been able to bring into my work and into every space that I am in. I found that there are a lot of ways that we can go into research thinking community first.
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New targeted therapies show promise in lung cancer treatment
Drug Target Review
DECEMBER 13, 2024
With a career spanning over two decades, Eleni has demonstrated her commitment to following the science, leading teams, and seeking improved ways to develop better medicines for patients in need. She holds an MD and PhD and has contributed to understanding mechanisms of resistance in acute leukemias.
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How do patent thickets vary across different countries
Drug Patent Watch
DECEMBER 10, 2024
Biotechnology and gene editing: Advances in biotechnology, particularly in areas like CRISPR gene editing, may create new patent thicket challenges in the life sciences sector. Internet of Things (IoT): The interconnected nature of IoT devices may lead to more complex patent thickets spanning multiple industries.
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AI Uses Zero-Shot Learning to Find Existing Drugs for Treating Rare Diseases
Nvidia Developer: Drug Discovery
OCTOBER 2, 2024
A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options.
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In-Silico Antibody Development with AlphaBind Using NVIDIA BioNeMo and AWS HealthOmics
Nvidia Developer: Drug Discovery
DECEMBER 3, 2024
Antibodies have become the most prevalent class of therapeutics, primarily due to their ability to target specific antigens, enabling them to treat a wide range.
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How GPCR agonists, including antibodies, are shaping the future of metabolic care
Drug Target Review
DECEMBER 4, 2024
G protein-coupled receptors (GPCRs) represent a cornerstone of modern drug discovery due to their crucial role in regulating human physiology and their involvement in numerous diseases. Many of these receptors are key targets for addressing obesity and metabolic disorders.
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Optimizing Drug Discovery with CUDA Graphs, Coroutines, and GPU Workflows
Nvidia Developer: Drug Discovery
OCTOBER 23, 2024
Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer. Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery.
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Virus that threatened humanity opens the future
Science Daily: Pharmacology News
DECEMBER 25, 2024
Scientists have developed an innovative therapeutic platform by mimicking the intricate structures of viruses using artificial intelligence (AI).
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How did humans and dogs become friends? Connections in the Americas began 12,000 years ago
Science Daily: Pharmacology News
DECEMBER 4, 2024
A new study sheds light on how long humans in the Americas have had relationships with the ancestors of today's dogs -- and asks an 'existential question': What is a dog?
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System to auto-detect new variants will inform better response to future infectious disease outbreaks
Science Daily: Pharmacology News
JANUARY 1, 2025
Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans -- including those causing flu, COVID, whooping cough and tuberculosis.
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Greenland fossil discovery reveals increased risk of sea-level catastrophe
Science Daily: Pharmacology News
AUGUST 5, 2024
Seeds, twigs, and insect parts found under two miles of ice confirm Greenland's ice sheet melted in the recent past, the first direct evidence that the center -- not just the edges -- of the two-mile-deep ice melted away in the recent geological past.
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NASA satellites reveal abrupt drop in global freshwater levels
Science Daily: Pharmacology News
NOVEMBER 16, 2024
The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.
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Scientists achieve more than 98% efficiency removing nanoplastics from water
Science Daily: Pharmacology News
AUGUST 13, 2024
Linked to cardiovascular and respiratory diseases in people, nanoplastics continue to build up, largely unnoticed, in the world's bodies of water. The challenge remains to develop a cost-effective solution to get rid of nanoplastics while leaving clean water behind. That's where Mizzou comes in.
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Link between global warming and rising sea levels
Science Daily: Pharmacology News
AUGUST 2, 2024
A new study suggests that Earth's natural forces could substantially reduce Antarctica's impact on rising sea levels, but only if carbon emissions are swiftly reduced in the coming decades. By the same token, if emissions continue on the current trajectory, Antarctic ice loss could lead to more future sea level rise than previously thought.
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Virus that causes COVID-19 is widespread in wildlife, scientists find
Science Daily: Pharmacology News
JULY 29, 2024
SARS-CoV-2, the virus responsible for COVID-19, is widespread among wildlife species, according to new research. The virus was detected in six common backyard species, and antibodies indicating prior exposure to the virus were found in five species, with rates of exposure ranging from 40 to 60 percent depending on the species.
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Cleaning up the aging brain: Scientists restore brain's trash disposal system
Science Daily: Pharmacology News
AUGUST 15, 2024
Scientists have restored the brain's waste-clearing process in aging mice, offering potential new treatment for Alzheimer's and Parkinson's using existing drugs.
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Placebos reduce stress, anxiety, depression -- even when people know they are placebos
Science Daily: Pharmacology News
AUGUST 23, 2024
A study found that nondeceptive placebos, or placebos given with people fully knowing they are placebos, effectively manage stress -- even when the placebos are administered remotely.
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Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds
Science Daily: Pharmacology News
SEPTEMBER 17, 2024
Consuming moderate amounts of coffee and caffeine regularly may offer a protective effect against developing multiple cardiometabolic diseases, including type 2 diabetes, coronary heart disease and stroke, according to new research.
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New AI can ID brain patterns related to specific behavior
Science Daily: Pharmacology News
SEPTEMBER 9, 2024
Scientists have developed a new AI algorithm that can separate brain patterns related to a particular behavior. This work promises to improve brain-computer interfaces and aid with the discovery of new brain patterns.
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Record-breaking recovery of rocks that originated in Earth's mantle could reveal secrets of planet's history
Science Daily: Pharmacology News
AUGUST 9, 2024
Scientists have recovered the first long section of rocks that originated in the Earth's mantle, the layer below the crust and the planet's largest component.
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New brain-computer interface allows man with ALS to 'speak' again
Science Daily: Pharmacology News
AUGUST 14, 2024
A new brain-computer interface translates brain signals into speech with up to 97 percent accuracy. Researchers implanted sensors in the brain of a man with severely impaired speech due to amyotrophic lateral sclerosis (ALS). The man was able to communicate his intended speech within minutes of activating the system.
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Hydrogels can play Pong by 'remembering' previous patterns of electrical simulation
Science Daily: Pharmacology News
AUGUST 22, 2024
Non-living hydrogels can play the video game Pong and improve their gameplay with more experience, researchers report.
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