BioPharma Drive: Drug Pricing

OCTOBER 4, 2024

An experimental Alzheimer’s therapy from Cassava Sciences is still being tested in two Phase 3 studies, even as the company has come under regulatory scrutiny.

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Trials Science Therapies 144

BioPharma Drive: Drug Pricing

OCTOBER 22, 2024

Early study data from Wave Life Sciences suggests how editing RNA may yield viable medicines. Large and small drugmakers say such results are just the start.

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RNA Science 141

Science Daily: Pharmacology News

DECEMBER 2, 2024

Results bring science one step closer to automating one of the most widely used methods in genomics research. New research suggests that large language models like GPT-4 could streamline the process of gene set enrichment, an approach what genes do and how they interact.

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Research Science 120

Science Daily: Pharmacology News

JANUARY 6, 2025

Collaborative work by amateur and professional astronomers has helped to resolve a long-standing misunderstanding about the composition of Jupiter's clouds. Instead of being formed of ammonia ice -- the conventional view -- it now appears they are likely to be composed of ammonium hydrosulphide mixed with smog.

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Science 63

DrugBaron

JANUARY 31, 2024

After decades slowly developing in the shadows, featuring more often in science fiction novels than television news programs, the arrival of large language models, and ChatGPT in particular, thrust artificial intelligence into the national consciousness. The subservience of “the science” to other factors in the decision-making process.

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Pharma R&D Science Small Molecule Drugs 165

Drug Target Review

DECEMBER 20, 2024

Smith identifies three key obstacles preventing broader acceptance of AI: Communication gaps : Pharmaceutical and computational science communities often struggle to understand each others technical languages, making collaboration difficult.

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Clinical Trials Trials Pharmaceuticals Drug Development 126

Broad Institute

JUNE 27, 2024

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain. Credit: Neumann EN, Bertozzi TM, et al.

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Disease Therapies Engineering Clinical Trials 142

DrugBaron

FEBRUARY 16, 2024

And today it has earned its place in the lexicon of life science venture capital, playing a key role in generating returns of investment houses across the globe. But it is not universal.

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Drug Development Pharma Companies Drugs Science 355

Drug Target Review

DECEMBER 9, 2024

the life sciences and pharmaceutical industries increasingly rely on AI-driven discoveries, companies operating in this space will need to carefully consider how to obtain meaningful protection for both the AI platforms and the products generated by such platforms.

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Engineering International Drug Development Science 105

Drug Patent Watch

DECEMBER 9, 2024

In the vast realm of pharmaceutical research and development, there’s a fascinating intersection between ancient wisdom and modern science. “Pharmacognosy is the bridge between traditional medicine and modern pharmaceutical science, offering a treasure trove of potential new drugs waiting to be discovered.”

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Drugs Drug Development Pharmaceuticals Production 92

Broad Institute

OCTOBER 28, 2024

To speed up the annotation step, the Broad Institute’s Data Sciences Platform (DSP) has developed a new search engine that automates much of this process by using machine learning to search data on more than 50 million annotated single cells. Tags: Data Sciences Platform Machine Learning Single Cell

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Engineering Cell Biology Disease RNA 119

Practical Cheminformatics

OCTOBER 8, 2024

Some Parting Thoughts on LLMs for Science Over the last year, there has been tremendous hype around applying LLMs in science. LLMs for science are still in their infancy, and the field is progressing rapidly. Of course, this is ridiculous.

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Fragment Screening Packaging Organic Chemistry Small Molecule 136

Codon

DECEMBER 12, 2024

” The report accompanies an article in Science , also released today, entitled “Confronting Risks of Mirror Life.” For the article in Science , more than 30 scientists from ten countries are calling on the broader community to confront the risks of mirrored life. ” But what, exactly, is a mirrored organism?

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DNA RNA Vaccine Virus 100

Drug Patent Watch

DECEMBER 12, 2024

Retrieved from [link] Life Science Leader. Retrieved from [link] Alira Health. 2022, September 8). Best Practices in the CDMO Selection Process. Retrieved from [link] Patheon. 2023, July 19). What is a CDMO and what to look for in a partner. 2023, February 23). How Industry Benchmarks Can Inform CDMO Selection. Retrieved from [link] Source

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Drug Development Production Clinical Trials Pharmaceutical Companies 94

Codon

JANUARY 5, 2025

Unfortunately, clinical results for many blood products made by Cohn’s team were inferior to other available treatment options, and perhaps that’s why his contributions to science have generally been forgotten. Cohn’s story can serve two practical purposes for those interested in new science organizations.

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Laboratories Production Science Research 73

The ChEMBL-og

OCTOBER 23, 2024

This will ultimately accelerate research in diverse fields, including drug discovery materials science, and advance our understanding of fundamental biological processes. BioChemGraph’s training material is now available! -> > BCG Training More information can be found in the official EBI communications article.

Small Molecule 117

Small Molecule Drugs Research Science 117

Drug Patent Watch

DECEMBER 10, 2024

The Science Behind Generic Drug Development. C., & Kern, S. Scientific Considerations for Global Drug Development. Retrieved from [link] East Street Pharmacy. Retrieved from [link] Source

Drug Development 95

Drug Development Pharmacokinetics Compliance Drugs 95

Broad Institute

SEPTEMBER 23, 2024

Scolnick Professorship, Ono Pharma Breakthrough Science Initiative Award, Merkin Institute Fellowship, Klarman Cell Observatory, and a National Institutes of Health New Innovator Award. “Such a tiny chemical change can contribute such an amazing increase to mRNA stability and translatability.” and Virginia W. Cabot Professorship, E.

RNA 134

RNA Vaccine Small Molecule Therapies 134

Broad Institute

OCTOBER 23, 2024

The DNA change underlying Emma’s disorder is now known, thanks to years of work by an international team of scientists and physicians at the Broad Institute of MIT and Harvard, Northwestern University, University of Nantes, the Weizmann Institute of Science, and the Baylor College of Medicine.

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DNA RNA Disease Hospitals 128

Codon

SEPTEMBER 29, 2024

While mRNA data was often illuminating, their interpretation was tricky; more akin to art than science. Models of life became the dominant research paradigm in nearly every life-sciences field. In short, the problem given to the model could be phrased as the following: given 19,980 mRNA values, predict values for the missing 20.

Engineering 133

Engineering Virus DNA Therapies 133

Drug Target Review

OCTOBER 30, 2024

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. 2017;23(1):49-59. Assembling human brain organoids. 2019;363(6423):126-7. Bleijs M, van de Wetering M, Clevers H, Drost J. Xenograft and organoid model systems in cancer research. 2019;38(15):e101654. Drost J, Clevers H. 2018;359(6378):920-6.

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Treatment Disease Clinical Trials Molecular Biology 105

Broad Institute

DECEMBER 11, 2024

Did that experience affect how you do science? We learned a lot about how to build community, and that's something I really value and I've been able to bring into my work and into every space that I am in. I found that there are a lot of ways that we can go into research thinking community first.

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Research DNA Clinical Research Science 105

Drug Target Review

DECEMBER 13, 2024

With a career spanning over two decades, Eleni has demonstrated her commitment to following the science, leading teams, and seeking improved ways to develop better medicines for patients in need. She holds an MD and PhD and has contributed to understanding mechanisms of resistance in acute leukemias.

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Therapies Treatment Clinical Trials Disease 98

Drug Patent Watch

DECEMBER 10, 2024

Biotechnology and gene editing: Advances in biotechnology, particularly in areas like CRISPR gene editing, may create new patent thicket challenges in the life sciences sector. Internet of Things (IoT): The interconnected nature of IoT devices may lead to more complex patent thickets spanning multiple industries.

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Licensing Licensing International Marketing 98

Nvidia Developer: Drug Discovery

OCTOBER 2, 2024

A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options.

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Disease Doctors Drugs Treatment 143

Nvidia Developer: Drug Discovery

DECEMBER 3, 2024

Antibodies have become the most prevalent class of therapeutics, primarily due to their ability to target specific antigens, enabling them to treat a wide range.

Small Molecule 134

Small Molecule Disease Drugs Science 134

Drug Target Review

DECEMBER 4, 2024

G protein-coupled receptors (GPCRs) represent a cornerstone of modern drug discovery due to their crucial role in regulating human physiology and their involvement in numerous diseases. Many of these receptors are key targets for addressing obesity and metabolic disorders.

Pharmacokinetics 122

Pharmacokinetics Small Molecule Therapies Immune Response 122

Science Daily: Pharmacology News

JANUARY 1, 2025

Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans -- including those causing flu, COVID, whooping cough and tuberculosis.

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Virus Disease Research 141

Science Daily: Pharmacology News

JANUARY 2, 2025

A research team has developed a method for extracting gold from electronics waste, then using the recovered precious metal as a catalyst for converting carbon dioxide (CO2), a greenhouse gas, to organic materials.

Research 134

Research 134

Science Daily: Pharmacology News

JANUARY 2, 2025

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

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Therapies Research 118

Science Daily: Pharmacology News

JANUARY 1, 2025

Waves of human migration across Europe during the first millennium AD have been revealed using a more precise method of analysing ancestry with ancient DNA, in research led by the Francis Crick Institute.

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DNA Research 131

Science Daily: Pharmacology News

DECEMBER 25, 2024

Scientists have developed an innovative therapeutic platform by mimicking the intricate structures of viruses using artificial intelligence (AI).

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Virus 135

Science Daily: Pharmacology News

JANUARY 3, 2025

Scientists recently discovered that the giant 'conveyer belt' currents that push star-forged material out of our galaxy and pull it back in can also transport carbon atoms. That means that a good deal of the carbon here on Earth, including the carbon in our bodies, likely left the galaxy at some point!

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Science Daily: Pharmacology News

JANUARY 2, 2025

Viral infections may play a role in Alzheimer's disease.

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Virus Disease 123

Science Daily: Pharmacology News

JANUARY 1, 2025

Scientists have identified the molecular changes that occur in the brains of aging mice and located a hot spot where much of that damage is centralized. The cells in the area are also connected with metabolism, suggesting a connection between diet and brain health.

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Research 123

Science Daily: Pharmacology News

AUGUST 5, 2024

Seeds, twigs, and insect parts found under two miles of ice confirm Greenland's ice sheet melted in the recent past, the first direct evidence that the center -- not just the edges -- of the two-mile-deep ice melted away in the recent geological past.

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Research 145

Science Daily: Pharmacology News

NOVEMBER 16, 2024

The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.

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