Science and Small Molecule - Drug Discovery Digest

$3M funding for plant-inspired halogenated small molecule drugs

Drug Discovery World

SEPTEMBER 28, 2023

Biomia says it plans to use the investment to accelerate its development of plant-inspired natural and new-to-nature halogenated small molecule drug candidates and further build its biosynthetic manufacturing platform.

Small Molecule

Small Molecule International Drugs Science

Small Molecule of the Year – 2022

Drug Hunter

APRIL 20, 2023

Through a series of structure-based design, ADME and solubility optimization, LP0200 was shown to exhibit high potency and safety comparable to approved IL-17A and IL-17RA targeting mAbs (more in our report of first disclosures from the EFMC-ISMC and this article on small molecule immunomodulators ). LP0200 has completed a Ph.

Small Molecule

Small Molecule Clinical Trials Trials Licensing

The future of drug discovery: Using AI to optimise the hit-to-lead process

Drug Discovery World

AUGUST 20, 2024

Mirit Eldor , Managing Director, Life Sciences Solutions, Elsevier, looks at how artificial intelligence (AI) can improve the hit-to-lead process for small molecules. Research shows that companies could shorten this cycle by up to 30 months 2 over the course of the small molecule drug discovery process by applying AI.

Small Molecule

Small Molecule Pharmaceutical Companies Drugs Pharmaceuticals

Turning science into business: Merging AI and RNA

Drug Discovery World

FEBRUARY 27, 2023

For founders planning to launch their start-ups, specifically drug developers, there needs to be sound, foundational science with promising data that will enable you to push further down the drug discovery pipeline. Do you have any therapeutic targets in mind for your first small molecule drug candidate?

RNA

RNA Science Small Molecule Engineering

AstraZeneca and Regeneron to research, develop and commercialise new small molecule medicines for obesity

The Pharma Data

JULY 28, 2021

Novel small molecule drug candidates will target GPR75 to potentially address obesity and related co-morbidities. AstraZeneca has entered into a collaboration with Regeneron to research, develop and commercialise small molecule compounds directed against the GPR75 target with the potential to treat obesity and related co-morbidities.

Small Molecule

Small Molecule Research Science Disease

Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2

Covalent Modifiers

FEBRUARY 6, 2024

Proceedings of the National Academy of Sciences 2024 , 121 (6), e2317756121. Gunaydin, H.; Boezio, A. McLean, T. Watters, J.; Bergstrom, D.

Small Molecule

Small Molecule Treatment Science Therapies

Tech Focus: How is HTS accelerating early-stage drug discovery?

Drug Discovery World

AUGUST 29, 2024

Now, with HT-SPR, researchers have the ability to screen entire antibody and small molecule libraries, along with characterising epitopes, so there is way more data available at the earliest stages of drug discovery than ever before.” The post Tech Focus: How is HTS accelerating early-stage drug discovery?

Small Molecule

Small Molecule Drugs Protein Expression Assay Development

Lead Pharma Teams with Roche on Oral Small Molecules for Immune-Mediated Diseases

The Pharma Data

NOVEMBER 17, 2020

Lead Pharma has entered into a collaboration and license agreement with Roche , hoping to lead the way in the development of oral small molecules for immune-mediated diseases like rheumatoid arthritis, psoriasis and inflammatory bowel diseases. .

Small Molecule

Small Molecule Disease Immune Response Licensing

2024 predictions: Experts comment on AI, ML and automation

Drug Discovery World

FEBRUARY 12, 2024

Cameron Ross, SVP, Generative AI, Elsevier “AI has the potential to dramatically shorten one of the most costly areas of early drug development – small molecule discovery. We’re already seeing biotechs making breakthroughs with AI in this area, with more than 150 small molecule drugs discovered and 15 already in clinical trials.

Small Molecule

Small Molecule Regulations Clinical Trials Therapies

Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling [@RulloLab]

Covalent Modifiers

AUGUST 14, 2024

Rullo Molecular Therapy 2024 DOI: [link] Proximity-induction of cell-cell interactions via small molecules represents an emerging field in basic and translational sciences. The molecules, termed covalent immune recruiters (CIRs), were designed to affinity label and covalently engage SARs.

Small Molecule

Small Molecule Engineering Science Therapies

Lilly and Kumquat Biosciences Announce Collaboration to Discover and Develop Novel Small Molecules that Stimulate Tumor-Specific Immune Responses

The Pharma Data

JULY 29, 2021

Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Kumquat Biosciences today announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses.

Small Molecule

Small Molecule Immune Response Research Laboratories Laboratories

‘Molecular switch’ could reverse the effects of alopecia

Drug Discovery World

AUGUST 15, 2024

A Phase IIa clinical trial has begun evaluating the safety and efficacy of Pelage Pharmaceuticals’ PP405, a novel topical small molecule, for the treatment of androgenetic alopecia (pattern baldness). The company is enrolling 60 women and men for the clinical study.

Small Molecule

Small Molecule Medical Schools Clinical Trials Pharmaceuticals

Elsevier and Iktos partner to launch AI-powered drug discovery database

Drug Discovery World

MARCH 11, 2024

The partnership aims to support R&D organisations to decrease the time required to complete Design-Make-Test-Analyse cycles of small molecules, thus reducing the length and cost of early-stage drug discovery.

Small Molecule

Small Molecule Drugs Science Production

SLAS2024: Day One Highlights

Drug Discovery World

FEBRUARY 5, 2024

Opening keynote Following a change to the schedule, Juliet Williams of Kymera Therapeutics launched the event with a popular keynote talk ‘Solving Big Problems with Small Molecule Degraders’. Life sciences and diagnostics company Revvity showcased over 40 products at SLAS2024, alongside new branding.

Small Molecule

Small Molecule Assay Development Production Science

Optibrium acquires BioPharmics

Drug Discovery World

SEPTEMBER 6, 2023

BioPharmics’ CEO, Dr Ajay Jain, and Director of Applied Science, Dr Ann Cleves, will join the Optibrium team, respectively focusing on R&D and Application Science in the newly-created BioPharmics Division. AI drug discovery company Optibrium has acquired 3D drug design specialist BioPharmics.

Small Molecule

Small Molecule Science Computational Chemistry Molecular Biology

CatSci adds cGMP analytical development services

Drug Discovery World

DECEMBER 1, 2023

UK-based CatSci have expanded their offering to now include cGMP analytical capabilities for both small molecule and oligonucleotides. The new cGMP analytical capability will be led by Dr Sam Whitmarsh and Duncan Thompson, CatSci’s Director of Analytical Science and Digital Transformation, and Head of Dagenham site respectively.

Small Molecule

Small Molecule Science Drugs

Turning science into business: An optimised alternative to antibodies

Drug Discovery World

APRIL 3, 2023

As life science operates globally, the vision for the business was always to bring aptamers as an antibody alternative to researchers worldwide. What advice would you offer to similar start-ups?    AT: Integral to Aptamer Group’s offering is an in-depth understanding of molecular science. To what do you attribute your success?

Science

Science Molecular Biology Therapies Small Molecule

AI in Drug Discovery - A Highly Opinionated Literature Review (Part III)

Practical Cheminformatics

JANUARY 16, 2024

Following up on Part I and Part II, the third post in this series is a collection of review articles published in 2023 that I found helpful.

Targeted Protein Degradation

Targeted Protein Degradation Small Molecule Computational Chemistry Bioinformatics

Podcast: The changing drug discovery and development landscape

Drug Discovery World

OCTOBER 20, 2022

They are called “ The potential of small molecules and biologics for new therapeutics ”, “ AE reporting turnarounds and the translation issue ” and “ Why we are on the cusp of a golden age of medicine ”. In the second article, Kathleen O’Brien of Amplexor Life Sciences lays out a blueprint for centralising global AE reporting.

Small Molecule

Small Molecule Pharmaceuticals Drugs Science

Lipid nanoparticles and mRNA used to treat hereditary blindness

Drug Discovery World

JANUARY 17, 2023

The study, led by OSU Associate Professor of Pharmaceutical Sciences Gaurav Sahay, Oregon State doctoral student Marco Herrera-Barrera, and Oregon Health & Science University Assistant Professor of Ophthalmology Renee Ryals, was published in Science Advances. . Limitations of AAV gene therapy .

Small Molecule

Small Molecule Pharmacy RNA Packaging

Lessons From A Private Funding Round: Science, Relationships, And Experience

LifeSciVC

APRIL 2, 2024

The quality of science – and the ability to distinguish it from other approaches – was the entry ticket to serious engagement. The science presents an opportunity and a challenge for us at Sionna. We experienced strong enthusiasm for small molecule research in the investor community. That science resonates with investors.

Science

Science Small Molecule International Clinical Development

Molecular glues could tackle ‘undruggable’ disease targets

Drug Discovery World

MAY 23, 2023

The investment includes a Prosperity Partnership grant from the Engineering and Physical Sciences Research Council (EPSRC) and matching funds from AstraZeneca. Challenges arise when we can’t find a small molecule with the ability to interact with certain proteins, those we call ‘undruggable’. million combined investment.

Disease

Disease Small Molecule Laboratories Engineering

What does the changing drug discovery and development landscape mean for the future?

Drug Discovery World

OCTOBER 20, 2022

They are called “ The potential of small molecules and biologics for new therapeutics ”, “ AE reporting turnarounds and the translation issue ” and “ Why we are on the cusp of a golden age of medicine ”. In the second article, Kathleen O’Brien of Amplexor Life Sciences lays out a blueprint for centralising global AE reporting.

Small Molecule

Small Molecule Drugs Pharmaceuticals Science

Covalent Modifiers - Untitled Article

Covalent Modifiers

JUNE 24, 2024

Rullo, Molecular Therapy: Oncology , 2024 , 200842, [link] Proximity-induction of cell-cell interactions via small molecules represents an emerging field in basic and translational sciences. The molecules, termed covalent immune recruiters (CIRs), were designed to affinity label and covalently engage SARs.

Small Molecule

Small Molecule Engineering Science Therapies

Evotec and Variant Bio partner to develop fibrosis treatments

Drug Discovery World

APRIL 24, 2024

Evotec will identify best-in-class small molecules targeting a key fibrotic pathway with strong genetic support identified by Variant Bio and progress the programme towards the selection of a clinical development candidate(s) using its R&D platform.

Treatment

Treatment Small Molecule Clinical Development Disease

Lab of the future uncovered at Tech Theatre, ELRIG Drug Discovery 2022

Drug Discovery World

SEPTEMBER 14, 2022

Building a global culture of sustainability in science. · . · How can automation help the discovery of biologics and biosimilars? Data handling and choosing the right informatics systems for your lab requirement. · The sustainable lab. The automated lab and the human. · The remote lab: Is this the future? · Fellowship Programme.

Small Molecule

Small Molecule Biosimilars Drugs Laboratories

UK Discovery Park plans centre of excellence for neuroscience

Drug Discovery World

NOVEMBER 18, 2022

One the UK’s largest science and innovation parks has revealed plans to double in size as it celebrates its ten-year anniversary. Focus on life sciences. The life sciences incubator will offer 50,000 sq ft of laboratory and office space for start-ups and early-stage companies, including biotech, medtech and digital health firms.

Small Molecule

Small Molecule Science Laboratories Production

Revolutionary molecular device unleashes potential for targeted drug delivery and self-healing materials

Science Daily: Pharmacology News

APRIL 10, 2024

In a new breakthrough that could revolutionise medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.

Small Molecule

Small Molecule Engineering Drugs

Key drug development trends and predictions for 2024

Drug Discovery World

FEBRUARY 19, 2024

Financial landscape In 2023, life science companies experienced a significant decrease in funding, particularly seed funding for early-stage drug development. In this article, she provides her expert insights into the key trends and developments expected to shape the global drug development industry this year.

Drug Development

Drug Development Small Molecule Drugs Therapies

Small Molecules Evolve

Drug Hunter

JUNE 11, 2023

Small molecule drugs make up most of the drugs we take conveniently as pills, including painkillers like ibuprofen (Advil), antibiotics like penicillin and amoxicillin, or cholesterol-lowering drugs like atorvastatin (Lipitor). The small molecules drugs of today look nothing like the molecules of the 1970s.

Small Molecule

Small Molecule Pharmaceuticals Engineering Treatment

$63m for allosteric modulators for neurological disorders

Drug Discovery World

APRIL 5, 2024

Neurosterix has launched with a $63 million Series A financing led by Perceptive Xontogeny Venture Fund II, with participation from Perceptive Life Sciences Fund and Acorn Bioventures. The company will acquire Addex’s allosteric modulator discovery technology platform.

Small Molecule

Small Molecule Therapies Treatment Science

Peptide–Drug Conjugates: An Emerging Direction for the Next Generation of Peptide Therapeutics

Covalent Modifiers

JANUARY 29, 2024

3c01835 Building on recent advances in peptide science, medicinal chemists have developed a hybrid class of bioconjugates, called peptide–drug conjugates, that demonstrate improved efficacy compared to peptides and small molecules independently. Moore Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01835

Small Molecule

Small Molecule Drugs Science Disease

Where are the hottest drug discovery hubs in the US?

Drug Discovery World

APRIL 27, 2023

In 2021, Savills put together a report on the regional hubs attracting science/pharma investment 1. The Boston Globe headline 3 , ‘Life sciences is poised to be Boston’s dominant industry. Over 450 life science companies including top pharmaceutical manufacturers are concentrated in the region.

Small Molecule

Small Molecule Science Drugs FDA Approval

ACI’s 4th Annual Passport to Proficiency on the Essentials of Hatch-Waxman and BPCIA – October 8-24, 2024 (Virtual)

FDA Law Blog: Biosimilars

AUGUST 27, 2024

Everyone in the life sciences industry must be well-versed in the regulatory components and intellectual property nuances integral to patenting products. Gain a comprehensive understanding of Hatch-Waxman and BPCIA essentials—critical competencies for legal and business professionals in the biopharmaceutical sector.

Small Molecule

Small Molecule FDA Regulations Production

RNA processing in health and disease: challenges and opportunities of the field

Drug Target Review

JUNE 15, 2023

In this article Drug Target Review’s Izzy Wood spoke to Sam Hasson, Director of Target Biology at Rgenta Therapeutics, a biotech firm in Massachusetts, US, that aims to develop small molecule therapeutics to target RNA processing. It is somewhat like how PROTACs have changed the perspective on what is a tractable therapeutic target.

RNA

RNA Small Molecule Disease Assay Development

Collaborators pursue anti-tau therapy for neurodegeneration

Drug Discovery World

JULY 17, 2023

IRBM, Rainwater Charitable Foundation and Weill Cornell Medicine will start of a multi-year drug discovery collaboration to identify small molecule cGAS (cyclic GMP-AMP synthase) inhibitors for the treatment of tauopathies and other neurodegenerative diseases.

Therapies

Therapies Small Molecule DNA Clinical Trials

Unlocking Undruggable Targets: Shifting Paradigms in Modern Drug Discovery

DrugBank

MAY 15, 2024

This method was more about serendipity than science. Today, we're able to identify and target specific molecules involved in disease processes—a method that's much more like using a sniper rifle than throwing darts blindfolded. One approach is to look beyond the traditional drug molecule.

Small Molecule

Small Molecule Molecular Biology Drugs Disease

Targeted protein degradation: turning undruggable targets into druggable targets

Drug Target Review

JULY 6, 2023

1 TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. 1 The concept of TPD was first demonstrated with a heterobifunctional small molecule to degrader a protein of interest in the early 2000s.

Targeted Protein Degradation

Targeted Protein Degradation Small Molecule Clinical Trials Science

Lost brain function restored in mice after stroke

Science Daily: Pharmacology News

NOVEMBER 30, 2023

Researchers have succeeded in restoring lost brain function in mouse models of stroke using small molecules that in the future could potentially be developed into a stroke recovery therapy.

Small Molecule

Small Molecule Therapies Research

Sosei Heptares’ COVID-19 Program Identifies Potent Broad Spectrum Anti-Viral Small Molecules for Further Development

The Pharma Data

NOVEMBER 19, 2020

The Company is also aiming to leverage the highly conserved structure of the SARS-CoV-2 M pro protease as a basis for the design of novel oral small molecules against predicted future variants of SARS-CoV-2 and other related human viruses. Zhang, et al, Science (2020) DOI: 10.1126/science.abb3405. References. Hilgenfeld, Febs J.

Small Molecule

Small Molecule Structure Based Drug Design (SBDD) Molecular Biology International

Scientists generate new targeted protein degradation system that tunes a cell’s own proteins

Broad Institute

MARCH 14, 2024

In one approach, they mark targeted proteins with “destroy me” tags that work with small molecules known as molecular glues to prompt the cell’s own protein-clearing machinery to gobble up the proteins. The new study appears in Science. Paper cited Mercer JAM, et al. March 14, 2024.

Targeted Protein Degradation

Targeted Protein Degradation Small Molecule Medical Schools Science

Cancer immunotherapy candidate provokes powerful dual response in cancer and immune cells

Broad Institute

OCTOBER 4, 2023

By Allessandra DiCorato October 4, 2023 Credit: AbbVie The new small molecule inhibitor (green) sits inside the PTPN2 protein, where acidic sites are marked in red and basic sites are marked in blue. A new small-molecule drug candidate being tested in an early-stage clinical trial aims to improve patient responses to immunotherapy.

Small Molecule

Small Molecule Clinical Trials Engineering Medical Schools

ICR and Merck renew cancer drug discovery alliance

Drug Discovery World

OCTOBER 4, 2023

Scientists in the Centre for Cancer Drug Discovery at the ICR will work with researchers at Merck to discover and develop new small-molecule inhibitors of an exciting new class of cancer targets. The post ICR and Merck renew cancer drug discovery alliance appeared first on Drug Discovery World (DDW).

Small Molecule

Small Molecule Drugs Clinical Trials Research

A simple, inexpensive way to make carbon atoms bind together

Science Daily: Pharmacology News

APRIL 5, 2024

The active ingredient in many drugs is what's known as a small molecule: bigger than water, much smaller than an antibody and mainly made of carbon. It's tough, however, to make these molecules if they require a quaternary carbon -- a carbon atom bonded to four other carbon atoms.

Small Molecule

Small Molecule Drugs

$3M funding for plant-inspired halogenated small molecule drugs

Small Molecule of the Year – 2022

Trending Sources

The future of drug discovery: Using AI to optimise the hit-to-lead process

Turning science into business: Merging AI and RNA

AstraZeneca and Regeneron to research, develop and commercialise new small molecule medicines for obesity

Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2

Tech Focus: How is HTS accelerating early-stage drug discovery?

Lead Pharma Teams with Roche on Oral Small Molecules for Immune-Mediated Diseases

2024 predictions: Experts comment on AI, ML and automation

Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling [@RulloLab]

Lilly and Kumquat Biosciences Announce Collaboration to Discover and Develop Novel Small Molecules that Stimulate Tumor-Specific Immune Responses

‘Molecular switch’ could reverse the effects of alopecia

Elsevier and Iktos partner to launch AI-powered drug discovery database

SLAS2024: Day One Highlights

Optibrium acquires BioPharmics

CatSci adds cGMP analytical development services

Turning science into business: An optimised alternative to antibodies

AI in Drug Discovery - A Highly Opinionated Literature Review (Part III)

Podcast: The changing drug discovery and development landscape

Lipid nanoparticles and mRNA used to treat hereditary blindness

Lessons From A Private Funding Round: Science, Relationships, And Experience

Molecular glues could tackle ‘undruggable’ disease targets

What does the changing drug discovery and development landscape mean for the future?

Covalent Modifiers - Untitled Article

Evotec and Variant Bio partner to develop fibrosis treatments

Lab of the future uncovered at Tech Theatre, ELRIG Drug Discovery 2022

UK Discovery Park plans centre of excellence for neuroscience

Revolutionary molecular device unleashes potential for targeted drug delivery and self-healing materials

Key drug development trends and predictions for 2024

Small Molecules Evolve

$63m for allosteric modulators for neurological disorders

Peptide–Drug Conjugates: An Emerging Direction for the Next Generation of Peptide Therapeutics

Where are the hottest drug discovery hubs in the US?

ACI’s 4th Annual Passport to Proficiency on the Essentials of Hatch-Waxman and BPCIA – October 8-24, 2024 (Virtual)

RNA processing in health and disease: challenges and opportunities of the field

Collaborators pursue anti-tau therapy for neurodegeneration

Unlocking Undruggable Targets: Shifting Paradigms in Modern Drug Discovery

Targeted protein degradation: turning undruggable targets into druggable targets

Lost brain function restored in mice after stroke

Sosei Heptares’ COVID-19 Program Identifies Potent Broad Spectrum Anti-Viral Small Molecules for Further Development

Scientists generate new targeted protein degradation system that tunes a cell’s own proteins

Cancer immunotherapy candidate provokes powerful dual response in cancer and immune cells

ICR and Merck renew cancer drug discovery alliance

A simple, inexpensive way to make carbon atoms bind together

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