Science Daily: Pharmacology News

MAY 16, 2024

In an important step toward more effective gene therapies for brain diseases, researchers have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein.

Therapies 318

Therapies Engineering Disease Research 318

Science Daily: Pharmacology News

APRIL 26, 2024

Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. However, the risk of arrhythmias following this procedure is reportedly high.

Therapies 318

Therapies Research 318

Science Daily: Pharmacology News

JANUARY 22, 2025

Treatment typically involves surgery and follow-up hormone therapy, but late effects of these treatments include osteoporosis, sexual dysfunction and blood clots. Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women.

Treatment 294

Treatment Therapies Drugs Research 294

Science Daily: Pharmacology News

JUNE 5, 2024

A new clinical trial of five children with inherited deafness found administering gene therapy in both ears led to restored hearing and speech, and additional gains including sound source localization, ability to hear in noisy environments, and for two children, abillity to appreciate music.

Therapies 309

Therapies Trials Clinical Trials International 309

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy, according to the new results of an international Phase III clinical trial.

Therapies 300

Therapies Clinical Trials International Trials 300

BioPharma Drive: Drug Pricing

OCTOBER 4, 2024

An experimental Alzheimer’s therapy from Cassava Sciences is still being tested in two Phase 3 studies, even as the company has come under regulatory scrutiny.

Trials 360

Trials Science Therapies 360

Science Daily: Pharmacology News

FEBRUARY 14, 2025

One day, researchers want to use switches of this kind to trigger cell therapies for various metabolic diseases. Researchers have developed a new gene switch that can be activated using a commercially available nitroglycerine patch applied to the skin.

Therapies 273

Therapies Disease Research 273

Drug Target Review

FEBRUARY 10, 2025

In the rapidly advancing field of cell therapies, Dr Jason Bock has emerged as a leader, known for his innovative approach to optimising the development process. With over 25 years of experience in therapeutics, Bock has played a pivotal role in shaping the future of cell therapies, particularly through his work at CTMC.

Therapies 64

Therapies Treatment Engineering Clinical Trials 64

Science Daily: Pharmacology News

JUNE 12, 2024

In April, the FDA warned of risk of secondary cancers in people receiving CAR-T cell therapy. A large study now finds the risk is low and not related to the CAR-T cells.

Therapies 280

Therapies FDA 280

Science Daily: Pharmacology News

JULY 12, 2024

Researchers have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of cells.

Therapies 231

Therapies Research 231

Science Daily: Pharmacology News

JULY 7, 2023

The mucus in the airways is not as sticky, inflammation in the lungs significantly reduced: Triple combination therapy can achieve these positive, lasting effects in patients with cystic fibrosis (CF). According to new research, this form of medication improves the symptoms of CF in many patients.

Therapies 253

Therapies Research 253

Science Daily: Pharmacology News

MAY 8, 2024

Investigators discovered that a subset of myeloid and lymphoid leukemias depend on a molecular complex called PI3Kgamma for survival.

Therapies 298

Therapies Clinical Trials Trials 298

Science Daily: Pharmacology News

AUGUST 30, 2023

A clinical trial has tested a potentially curative stem cell gene therapy for sickle cell disease. The results were promising.

Therapies 218

Therapies Clinical Trials Trials Disease 218

Science Daily: Pharmacology News

JANUARY 24, 2024

A novel gene therapy for hearing loss was administered to six children in China in a clinical trial. Each child had an inherited deafness caused by mutations in the OTOF gene, called DFNB9.

Therapies 216

Therapies Clinical Trials Trials Research 216

Science Daily: Pharmacology News

AUGUST 31, 2023

A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer. Scientists have demonstrated the potential efficacy of this approach a preclinical study.

Therapies 250

Therapies 250

Science Daily: Pharmacology News

MARCH 13, 2025

Researchers devised a process to convert a skin cell directly into a neuron, eliminating the need to generate induced pluripotent stem cells. Such neurons could be used to treat spinal cord injuries or diseases such as ALS.

Engineering 280

Engineering Therapies Disease Research 280

Science Daily: Pharmacology News

JULY 12, 2023

They also found that co-transplantation of neuronal cell therapy with host regulatory T cells resulted in effective suppression of needle trauma and significant improvement in the survival and recovery of grafts. These findings suggest a path for the 'realistic' use of cell therapy to treat neurodegenerative disorders.

Therapies 189

Therapies Immune Response Disease Research 189

Science Daily: Pharmacology News

MAY 30, 2024

Scientists have found that statins -- commonly used cholesterol-lowering drugs -- may block a pathway that leads to the development of cancer in the context of chronic inflammation.

Therapies 297

Therapies Drugs 297

Science Daily: Pharmacology News

OCTOBER 18, 2023

Results demonstrated the safety and preliminary efficacy of the novel gene therapy approach in high-grade glioma patients, with prolonged survival in a subgroup of recurrent GBM patients immunologically 'familiar' with the virus.

Therapies 217

Therapies Immune Response Research Virus 217

BioPharma Drive: Drug Pricing

MARCH 7, 2025

Elsewhere, AskBio advanced a gene therapy and Pfizer hired a scientist well versed in GLP-1 science. The Swiss pharma will base cardiometabolic drug research at the new Allston site.

Science 221

Science Therapies Drug Research Research 221

BioPharma Drive: Drug Pricing

JUNE 3, 2024

With new modalities such as gene and cell therapies, RNA therapeutics, complex biologics and more, today’s science brings unprecedented opportunities to address diseases that have long remained out of reach.

Science 139

Science RNA Therapies Disease 139

Science Daily: Pharmacology News

AUGUST 30, 2023

Scientists have made a `paradigm shifting' discovery on the mechanisms required for learning and memory that could lead to new therapies for Alzheimer's disease and potentially Down syndrome.

Therapies 224

Therapies Disease 224

Science Daily: Pharmacology News

NOVEMBER 13, 2023

This discovery opens up new opportunities for therapeutic intervention to control cholesterol uptake that could complement other therapies and potentially save lives. Researchers have discovered the mechanism by which cholesterol in our diet is absorbed into our cells.

Therapies 234

Therapies Disease Research 234

Science Daily: Pharmacology News

JUNE 21, 2024

Menthol sensing appeared long before cold sensing, suggesting distinct activation modes that can be disentangled, paving the way for new pain therapies without adverse thermal side effects.

Therapies 220

Therapies 220

Science Daily: Pharmacology News

FEBRUARY 22, 2024

A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, including by reducing the number of people requiring urgent abdominal surgery for treatment of their disease by ten-fold.

Therapies 222

Therapies Clinical Trials Treatment Disease 222

Science Daily: Pharmacology News

AUGUST 9, 2023

Promising preclinical results show hematopoietic stem cell therapy was effective in rescuing memory loss, neuroinflammation and beta amyloid build-up in a mouse model of Alzheimer's disease.

Therapies 189

Therapies Disease 189

Drug Target Review

MARCH 4, 2025

Phenomix Sciences , led by CEO Mark Bagnall, is using precision medicine to make treatments more targeted and effective. Phenomix Sciences, built on over a decade of clinical research at the Mayo Clinic, is disrupting this outdated approach. Meet Mark Bagnall Mark Bagnall currently serves as CEO of Phenomix Sciences, Inc.

Therapies 52

Therapies Treatment Clinical Trials Science 52

Science Daily: Pharmacology News

JULY 31, 2023

Pain experts suggest that scrambler therapy, a noninvasive pain treatment, can yield significant relief for approximately 80% -- 90% of patients with chronic pain, and it may be more effective than another noninvasive therapy: transcutaneous electrical nerve stimulation (TENS).

Therapies 190

Therapies Treatment 190

Science Daily: Pharmacology News

JULY 5, 2023

An antisense therapy restores production of the protein FMRP in cell samples taken from patients with fragile X syndrome.

Protein Production 189

Protein Production Production Therapies RNA 189

Broad Institute

MAY 16, 2024

Gene therapy could potentially treat a range of severe genetic brain disorders, which currently have no cures and few treatment options. Since we came to the Broad we’ve been focused on the mission of enabling gene therapies for the central nervous system,” said Deverman, senior author on the study. “If

Therapies 137

Therapies FDA Approval Engineering Disease 137

Broad Institute

JUNE 27, 2024

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain.

Disease 142

Disease Therapies Clinical Trials Engineering 142

Broad Institute

FEBRUARY 27, 2025

An ancient RNA-guided system could simplify delivery of gene editing therapies By Corie Lok February 27, 2025 Breadcrumb Home An ancient RNA-guided system could simplify delivery of gene editing therapies The programmable proteins are compact, modular, and can be directed to modify DNA in human cells. Lisa Yang and Hock E.

RNA 66

RNA Therapies DNA Virus 66

Science Daily: Pharmacology News

AUGUST 9, 2023

A study shows new steps toward more patients getting gene therapy.

Therapies 170

Therapies Research 170

Codon

FEBRUARY 13, 2024

Tom Ireland writes about the companies and technologies that are reimagining phage therapy. Soon after its publication, scientists, journalists, and investors were revisiting ‘phage therapy’ as a promising alternative to our failing antibiotics. Read it on our website here. Illustration by David S. Fast forward to 2023.

Therapies 128

Therapies Virus DNA Clinical Trials 128

Science Daily: Pharmacology News

AUGUST 9, 2024

A 'loopy' discovery in bacteria is raising fundamental questions about the makeup of our own genome -- and revealing a potential wellspring of material for new genetic therapies.

Therapies 358

Therapies 358

Drug Discovery Today

FEBRUARY 4, 2022

• Face-to-face event, taking place in London, UK, 26-27th April, will feature two dedicated tracks: ‘Scientific’, focused on seven core therapy areas and ‘Life Sciences Business’ Programme features keynote from George Freeman MP, with an update on the UK Government Life Sciences VisionRegistration for BioTrinity 2022 now available online

Science 113

Science Government Therapies 113

Science Daily: Pharmacology News

JULY 26, 2024

New therapy uses synthetic nanofibers to mimic the natural signaling of a protein that is crucial for cartilage formation and maintenance. Therapy could be used to treat osteoarthritis, which affects nearly 530 million people worldwide. After just four hours, the treatment activated the gene expression necessary to generate cartilage.

Therapies 322

Therapies Treatment Research 322