Science Daily: Pharmacology News

MARCH 27, 2025

Researchers conducted the first clinical trial of an AI-powered therapy chatbot and found that, on average, people with diagnosed mental disorders experienced clinically significant improvements in their symptoms over eight weeks, according to new results.

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Therapies Trials Clinical Trials Research 315

Science Daily: Pharmacology News

MAY 17, 2024

An HIV vaccine candidate triggered low levels of an elusive type of broadly neutralizing HIV antibodies among a small group of people enrolled in a 2019 clinical trial.

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Vaccine Trials Clinical Trials 337

PPD

JANUARY 15, 2025

As clinical trials become increasingly complex, particularly in decentralized trials and rare disease studies, sponsors experience increased challenges in site selection, forecasting and resourcing, and patient recruitment and enrollment. Discover how AI is used to optimize key aspects of clinical trial management. Get in touch.

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Clinical Trials Trials Clinical Research Drug Development 95

Science Daily: Pharmacology News

SEPTEMBER 2, 2024

Finerenone reduced the composite of total first and recurrent heart failure (HF) events (hospitalizations for HF or urgent HF visits) and cardiovascular death in patients with HF and mildly reduced or preserved ejection fraction, according to an international clinical trial.

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Clinical Trials Trials Hospitals International 317

Science Daily: Pharmacology News

APRIL 29, 2024

The phase 1/2 randomized trial compared results from the measles and rubella vaccine delivered by a microarray patch, a small sticking plaster-like device with an array of microscopic projections that painlessly penetrate the skin and deliver the vaccine, or by conventional injection with a needle and syringe.

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Vaccine Trials Immune Response 310

Science Daily: Pharmacology News

NOVEMBER 27, 2024

Recent results from a recent clinical trial indicate that a twice-yearly injection of Lenacapavir offers an overall 96% reduced risk of acquiring HIV. This makes Lenacapavir significantly more effective than the standard daily oral PrEP (pre-exposure prophylaxis).

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Clinical Trials Trials 319

Science Daily: Pharmacology News

JUNE 5, 2024

A new clinical trial of five children with inherited deafness found administering gene therapy in both ears led to restored hearing and speech, and additional gains including sound source localization, ability to hear in noisy environments, and for two children, abillity to appreciate music.

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Therapies Trials Clinical Trials International 315

Science Daily: Pharmacology News

MARCH 5, 2025

The scientists say that discovering the mechanism will support ongoing clinical trials, and could lead to the targeted use of aspirin to prevent the spread of susceptible types of cancer, and to the development of more effective drugs to prevent cancer metastasis.

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Clinical Trials Trials Drugs 319

Drug Target Review

DECEMBER 20, 2024

However, recent breakthroughs in AI, such as predictive modelling, clinical trial optimisation, and personalised medicine, have demonstrated its potential. We spoke with Aaron Smith, a mathematician-turned-machine learning scientist and the founder of Unlearn , a company leading the charge in applying AI to optimise clinical trial efficiency.

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Clinical Trials Trials Pharmaceuticals Drug Development 128

BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

Applying a systems thinking approach can create improvements in scientific integrity, operational feasibility and scalability.

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Clinical Trials Science Trials 217

BioPharma Drive: Drug Pricing

JUNE 24, 2024

Benefits of adopting the systems thinking approach in clinical trial design.

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Clinical Trials Trials Science 152

BioPharma Drive: Drug Pricing

JULY 3, 2023

What is the GDPR and why does it matter to your life sciences company. iliomad Health Data can help you maintain GDPR compliance.

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Trials Compliance Science 246

Drugs.com

SEPTEMBER 12, 2024

That's according to new trial results released Thursday by Gilead Sciences. THURSDAY, Sept. 12, 2024 -- It could be a real breakthrough for people at risk for HIV infection: A shot given every six months that reduces their risk by a whopping 96%.That's

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Science Trials 298

Science Daily: Pharmacology News

DECEMBER 10, 2023

Leukaemia trial shows 'exceptional' results. Personalized treatment for the most common form of adult leukemia helps patients survive for longer and stay in remission, a phase III trial has found.

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Trials Treatment Disease Drugs 221

Science Daily: Pharmacology News

SEPTEMBER 6, 2024

The vision of people with a rare inherited condition that causes them to lose much of their sight early in childhood was 100 times better after they received gene therapy to address the genetic mutation causing it.

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Therapies Trials Research 330

BioPharma Drive: Drug Pricing

SEPTEMBER 26, 2023

Much anticipated clinical trial data for Immunovant’s experimental FcRn inhibitor could catalyze business development decisions for its parent, Roivant Sciences.

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Clinical Trials Disease Science Trials 268

Fierce BioTech

OCTOBER 5, 2023

Successful and worthwhile clinical trials rely on patient trust throughout the entire experience. Greg Lever, Director within the IQVIA Applied Data Science Center, reveals how modeling technology is being used to unlock value and enhance the experience of trial participants.

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Clinical Trials Trials Science 115

Conversations in Drug Development Trends

AUGUST 10, 2023

I was fortunate to have the opportunity to attend Psychedelic Science 2023 during the third week of June in Denver, Colorado. The event provided a unique opportunity to interact with a large and diverse group of fellow stakeholders, expanding my perspective on the impact of psychedelic clinical trials.

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Science Clinical Trials Trials Clinical Research 98

Science Daily: Pharmacology News

AUGUST 18, 2023

Novel stem cell therapy called a CALEC transplant was performed safely in four patients with serious chemical burns tracked in a phase I clinical trial for 12 months. The patients experienced early clinical gains: two were able to undergo a corneal transplant and two reported significant improvements in vision without additional treatment.

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Therapies Trials Clinical Trials Treatment 188

Science Daily: Pharmacology News

MARCH 19, 2025

The findings suggest -- for the first time in a clinical trial -- that early treatment to remove amyloid plaques from the brain many years before symptoms arise can delay the onset of Alzheimer's dementia.

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Clinical Trials Drugs Trials Treatment 313

Science Daily: Pharmacology News

APRIL 15, 2024

Researchers have discovered that an FDA-approved epilepsy drug can prevent or slow the growth of NF1-linked optic gliomas in mice, laying the groundwork for a clinical trial.

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FDA Approval Clinical Trials Drugs FDA 333

Drug Target Review

APRIL 7, 2025

A surrogate endpoint is a marker used in clinical trials as a substitute for a direct clinical outcome. Diagnostic biomarkers typically confirm or establish a diagnosis and are often used in selecting patient populations for clinical trials.

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Clinical Development Clinical Trials Clinical Pharmacology Trials 59

Science Daily: Pharmacology News

AUGUST 6, 2024

A new study details the findings from a five-year interventional randomized control trial. Diets high in fruits and vegetables are found to lower blood pressure, reduce cardiovascular risk, and improve kidney health due to their base-producing effects.

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Doctors Trials Treatment 336

Science Daily: Pharmacology News

NOVEMBER 27, 2023

An international team has shown that the injection of a type of stem cell into the brains of patients living with progressive multiple sclerosis (MS) is safe, well tolerated and has a long-lasting effect that appears to protect the brain from further damage.

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Therapies Trials International 242

Antidote

FEBRUARY 27, 2023

Participating in a clinical trial has many benefits, including working with condition specialists, getting access to personalized medical care, and helping science move forward — but did you know that some clinical trials offer compensation, as well?

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Clinical Trials Trials Science 98

Fierce BioTech

SEPTEMBER 5, 2024

How can life sciences organizations effectively identify and recruit participants with specific genetic variants? png Listing Introduction Explore how incorporating genetic services can increase identification of patients who meet trial-specific inclusion/exclusion criteria, helping more patients benefit from life-changing therapeutics.

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Trials Disease Clinical Trials Therapies 87

Science Daily: Pharmacology News

NOVEMBER 27, 2024

A recent trial finds an injection given during some asthma and COPD attacks is more effective than the current treatment of steroid tablets, reducing the need for further treatment by 30%.

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Treatment Trials 314

Drug Target Review

JANUARY 8, 2024

We hope to initiate the first human clinical trials with our lead indications in 2025, which would represent a monumental step forward for the field of cellular rejuvenation. With significant validation of our platform in hand, we are now rapidly advancing towards the clinic with our lead therapeutic, OSK.

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Science Disease FDA Approval Clinical Trials 145

PPD

JUNE 24, 2024

In the realm of vaccine development, mega trials — studies enrolling 5,000 subjects or more — have been instrumental in the fight against many pathogens, including influenza, rotavirus, malaria, RSV and most recently in the rapid development of vaccines against COVID-19.

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Vaccine Trials Clinical Trials Laboratories 97

Science Daily: Pharmacology News

FEBRUARY 25, 2025

A bone marrow transplant process is safe and curative for adults with sickle cell disease, according to results of a trial completed at about 20 cancer centers.

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Disease Trials 309

Science Daily: Pharmacology News

AUGUST 28, 2024

Preliminary trials show the therapy relieves pain after a single treatment. Engineers have developed a device that noninvasively stimulates deep brain regions, potentially disrupting the faulty signals that lead to chronic pain.

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Engineering Therapies Trials Treatment 304

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy, according to the new results of an international Phase III clinical trial.

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Therapies Clinical Trials International Trials 305

Science Daily: Pharmacology News

MARCH 20, 2025

During trials involving traffic noise, Galapagos yellow warblers (Setophaga petechia aureola) increased the duration of their songs, increased the minimum frequencies of their songs (to reduce overlap with the traffic noise), and birds living close to roads displayed increased physical aggression.

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Trials 278

Science Daily: Pharmacology News

MAY 8, 2024

The study provides both mechanistic and preclinical evidence supporting the rapid initiation of clinical trials for patients with acute myeloid leukemia (AML) to test an existing medicine that inhibits the complex, called eganelisib, both alone and in combination with the most used AML chemotherapy, cytarabine.

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Therapies Clinical Trials Trials 304

Science Daily: Pharmacology News

OCTOBER 17, 2024

The results will pave the way for clinical trials of the vaccine. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust immune response, promote clearance of existing C.

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Vaccine Immune Response Clinical Trials Trials 315

Drug Target Review

MARCH 24, 2025

Sujeegar Jeevanandam, an expert with 13 years of experience in life sciences R&D, offers valuable insights into the current state and future trajectory of artificial intelligence in drug discovery. Currently, understanding these aspects requires extensive animal testing followed by human trials.

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Clinical Trials Animal Testing Drugs Pharmacokinetics 59

Science Daily: Pharmacology News

JUNE 18, 2024

Clinical trials in humans are now planned. The discovery could lead to more targeted treatments, with fewer side-effects, for issues from lengthy COVID infections to autoimmune diseases like multiple sclerosis.

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Treatment Immune Response Disease Clinical Trials 338