Covalent Modifiers

FEBRUARY 1, 2024

Covalent and noncovalent inhibitors of BTK have revolutionized the treatment of these cancers. We therefore set out to understand the nonenzymatic functions of BTK and explored targeted protein degradation to overcome the oncogenic scaffold function of mutant BTK.

Targeted Protein Degradation 173

Targeted Protein Degradation Clinical Trials Trials Science 173

The Pharma Data

JULY 22, 2021

NYSE: PFE) today announced a global collaboration to develop and commercialize ARV-471, an investigational oral PROTAC® (PROteolysis TArgeting Chimera) estrogen receptor protein degrader. Despite advancements in oncology in recent years, considerable unmet need persists in the treatment of HR+ breast cancer.

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Targeted Protein Degradation Therapies Clinical Trials Treatment 52

The Pharma Data

DECEMBER 15, 2020

Nasdaq: ARVN), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein degradation using its PROTAC ® Discovery Engine, today announced the pricing of an underwritten public offering of 5,714,286 shares of its common stock at a price of $70.00 NEW HAVEN, Conn., Forward-Looking Statements.

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Targeted Protein Degradation Engineering Clinical Trials Disease 40

Drug Hunter

AUGUST 21, 2023

Overall, only a few prodrugs for CNS disorders have even reached clinical trials , so for the most part traditional property-based drug design remains the best bet for the vast majority of programs. Figure 19: Compound 7 is highly effective in a mouse model of HAT infection, leading to cures after six days of treatment. Figure 18.

Drugs 206

Drugs Disease Targeted Protein Degradation Screening Hits 206