Sat.Dec 14, 2024 - Fri.Dec 20, 2024

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Mysteries of icy ocean worlds

Science Daily: Pharmacology News

A study introduces a novel thermodynamic concept called the 'centotectic' and investigates the stability of liquids in extreme conditions -- critical information for determining the habitability of icy moons like Europa.

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In Silico‐Designed G‐Quadruplex Targeting Peptide Attenuates VEGF‐A Expression, Preventing Angiogenesis in Cancer Cells

Chemical Biology and Drug Design

The polypurine/polypyrimidine (pPu/pPy) tract, located in the proximal 36-bp region of the VEGF-A promoter(80 and 50), can switch between G-quadruplex and duplex structures, acting as a transcriptional inhibitor/activator between 85 and 50. Peptide ligands target and stabilise the VEGF G-quadruplex, thus lowering transcription and inhibiting angiogenesis.

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Study Supports Tamoxifen for DCIS Early Breast Cancers

Drugs.com

MONDAY, Dec. 16, 2024 -- The established hormone therapy drug tamoxifen can significantly decrease the risk of cancer recurring in women with an early, low-risk form of breast cancer, a new study says. Women who took tamoxifen after undergoing a.

Therapies 101
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Sanofi, Teva say study results show gut disease drug could be ‘best in class’

BioPharma Drive: Drug Pricing

Phase 2 results in inflammatory bowel disease hinted the therapy could be more potent than similar medicines from Merck and Roche, each of which were acquired in multibillion-dollar deals.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Syphilis had its roots in the Americas

Science Daily: Pharmacology News

A research team has taken a crucial step towards resolving a long-standing controversy -- was syphilis introduced to Europe from the Americas at the end of the 15th century, or had it been there all along? Ancient pathogen genomes from skeletons that pre-date 1492 confirm its introduction from the Americas, but its world-wide spread remains a grim legacy of the colonial period.

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The Importance of CDMO Flexibility: Adapting to the Ever-Changing Pharmaceutical Landscape

Drug Patent Watch

Flexibility has become more than just a buzzword it’s a necessity. Contract Development and Manufacturing Organizations (CDMOs) are at the forefront of this shift, playing a crucial role in bringing innovative therapies to market. But what exactly makes flexibility so important for CDMOs, and how can they cultivate this essential trait? Let’s dive into the world of pharmaceutical outsourcing and explore why adaptability is the key to success.

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Novo’s next-gen obesity drug misses expectations in closely watched trial

BioPharma Drive: Drug Pricing

Novo shares lost nearly a quarter of their value after an experimental combination treatment called cagrisema fell short of the bar set by executives.

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Microplastics in the air may be leading to lung and colon cancers

Science Daily: Pharmacology News

Tires and degrading garbage shed tiny pieces of plastic into the air, creating a form of air pollution that researchers suspect may be causing respiratory and other illnesses.

Research 112
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How AI will reshape pharma by 2025

Drug Target Review

Artificial intelligence (AI) has revolutionised many industries, yet its adoption in pharmaceutical drug development has been notably slower. Concerns surrounding data security, the complexity of AI systems, and the rigorous regulatory frameworks in this field have caused the pharmaceutical industry to approach these technologies with caution. For years, AI and machine learning (ML) were often dismissed as little more than advanced statistics with little practical value in drug development.

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Could Olumiant Be A New Way to Treat Sjögren’s Disease? Researchers Are Hopeful

Drugs.com

FRIDAY, Dec. 20, 2024 -- An existing drug might be able to treat an autoimmune disorder that causes dry eye, dry mouth, fatigue and muscle or joint pain. Baricitinib (Olumiant), a drug currently used to treat rheumatoid arthritis, appears to.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Zepbound, Mounjaro shortages are resolved, FDA confirms

BioPharma Drive: Drug Pricing

The FDA’s decision will close a lucrative market opportunity for compounding pharmacies, although the agency will give a limited grace period before taking any enforcement actions.

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Massive black hole in the early universe spotted taking a 'nap' after overeating

Science Daily: Pharmacology News

Scientists have spotted a massive black hole in the early universe that is 'napping' after stuffing itself with too much food. Like a bear gorging itself on salmon before hibernating for the winter, or a much-needed nap after Christmas dinner, this black hole has overeaten to the point that it is lying dormant in its host galaxy.

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Microbiological Applications: Bacterial Metabolism | BMG LABTECH

BMG Labtech

Bacterial metabolism applications Bacterial metabolism spans the complex interconnected set of chemical reactions that support life in bacteria, ancient single-celled organisms that represent one of the most diverse forms of life on Earth. Bacterial metabolism is the foundation for bacterial growth and is inextricably linked to other organisms in the ecosystem.

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Artificial Sweetener Use Tied to Less-Healthy Diets

Drugs.com

WEDNESDAY, Dec. 18, 2024 -- Folks who switch to artificial sweeteners in drinks and food may be drawn to other types of unhealthy fare -- bringing down the quality of their overall diet, new research suggests.The study, published recently in the.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Merck targets 2025 RSV season with antibody now under FDA review

BioPharma Drive: Drug Pricing

An FDA approval of Merck’s drug clesrovimab by June would give physicians another option for protecting newborns from respiratory syncytial virus.

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Carnivorous squirrels documented in California

Science Daily: Pharmacology News

California ground squirrels hunt, kill and eat voles, reveals a new study documenting evidence of widespread carnivorous behavior among squirrels.

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Universal Design for Visual Disabilities in Healthcare – Addressing Complete Blindness – 6

Perficient: Drug Development

Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. Creating an inclusive healthcare environment for individuals with complete blindness is a fundamental aspect of universal design. These individuals rely heavily on non-visual cues to navigate, access information, and communicate effectively.

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U.S. Woman Living Healthy With Kidney Sourced From Pig

Drugs.com

TUESDAY, Dec. 17, 2024 -- A 53-year-old woman from Alabama has a new lease on life after receiving a gene-edited kidney obtained from a pig, living healthily with the new organ for over a month, her New York City doctors announced Tuesday. Towana.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Merck calls quits on two immunotherapies for cancer

BioPharma Drive: Drug Pricing

The company is scrapping two drugs aimed at targets called TIGIT and LAG-3, both of which were in the middle of Phase 3 testing.

Drugs 69
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Massive volcanic eruptions did not cause the extinction of dinosaurs

Science Daily: Pharmacology News

While volcanism caused a temporary cold period, the effects had already worn off thousands of years before the meteorite, the ultimate cause of the dinosaur extinction event, impacted.

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Keypoint Newsletter: Introducing the New Fellows Class of 2025

keypoint

Meet the Keystone Symposia Fellows Class of 2025, a stellar group of post-doctoral fellows and early-career scientists who will take part in this prestigious mentorship program.

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Allergies Have You Stuffed Up? Nose Fungi May Be to Blame

Drugs.com

TUESDAY, Dec. 17, 2024 -- There’s fungus among us, and it might be making allergies and asthma worse. People with allergy sniffles and asthma have different fungal colonies in their noses than folks who don’t suffer respiratory.

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Merck moves into obesity with deal for Hansoh’s GLP-1 pill

BioPharma Drive: Drug Pricing

News of Merck’s licensing of Hansoh’s preclinical medicine pressured shares in Viking and other obesity drug developers seen as likely buyout targets.

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A 'remelting' of lunar surface adds a wrinkle to mystery of Moon's true age

Science Daily: Pharmacology News

Scientists propose a 'remelting' of the Moon's surface 4.35 billion years ago due to the tidal pull of Earth causing widespread geological upheaval and intense heating.

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Universal Design for Visual Disabilities in Healthcare – Clear and Accessible Communication – 4

Perficient: Drug Development

Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. Effective communication is vital in healthcare, and ensuring that it is accessible to individuals with visual disabilities is an essential aspect of universal design. Clear and accessible communication methods help patients understand their health information, engage with their care, and make informed decisions.

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Team Sports Score Big Points for Your Child's Brain, Study Finds

Drugs.com

TUESDAY, Dec. 17, 2024 -- There may be something special about team sports in childhood that helps sharpen a kids' brain, new research shows. Children who were on soccer or volleyball teams scored higher on tests of "executive function" -- thinking.

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A venture firm breathes new life into an old NGM drug

BioPharma Drive: Drug Pricing

An startup formed by KdT Ventures intends to test the drug, which was once licensed to Merck and evaluated in multiple metabolic disorders, for an unspecified rare conditon.

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Naughty or Nice? Many parents rely on threats to manage misbehavior -- from no dessert to no Santa

Science Daily: Pharmacology News

When young children's behavior becomes challenging, many parents resort to threats -- from taking away toys to threatening that Santa will skip their house, a national poll suggests.

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Curves Module Insights

Collaborative Drug

Learn how CDD Vault is utilizing Curves to improve your drug discovery process.

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FDA: Veozah, First Hormone-Free Hot Flash Drug, Issued Black Box Warning

Drugs.com

WEDNESDAY, Dec. 18, 2024 -- The U.S. Food and Drug Administration (FDA) has issued its most serious warning -- a black-box warning -- for Veozah, a medication used to relieve hot flashes in menopausal women, due to rare but potentially severe liver.

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Regeneron says study data support big bet on new blood thinners

BioPharma Drive: Drug Pricing

The company is planning a “broad Phase 3 program” for two anticoagulants after they outperformed marketed medicines in a pair of mid-stage trials.

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Physicists 'bootstrap' validity of string theory

Science Daily: Pharmacology News

String theory remains elusive as a 'provable' phenomenon. But a team of physicists has now taken a significant step forward in validating string theory by using an innovative mathematical method that points to its 'inevitability.

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Keypoint Newsletter: A Message from Our CEO

keypoint

Keystone Symposia CEO shares his first impressions, improvement and initiatives that will be implemented in 2025.

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