Sat.Nov 16, 2024 - Fri.Nov 22, 2024

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NASA satellites reveal abrupt drop in global freshwater levels

Science Daily: Pharmacology News

The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.

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Diabetes Meds Metformin, GLP-1s Can Also Curb Asthma

Drugs.com

MONDAY, Nov. 18, 2024 -- Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows.The two drugs are metformin, one of the most widely used diabetes medications, and the.

Research 126
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Caring for Yourself While Caring for Others: Practical Tips for Caregivers

Antidote

Being a caregiver is one of the most selfless and demanding roles you can take on. Whether you're looking after a parent, spouse, child, or loved one, juggling all of the daily responsibilities that come with it can quickly feel overwhelming. With so much focus on taking care of others, it’s easy to put yourself and your needs on the back burner. While your focus is understandably on your loved one, it’s important to remember that your own well-being matters too.

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The Emotional Conclusion : Project Estimating (Part 4)

Perficient: Drug Development

This post is the third in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Part 2: Dependencies & Creep Part 3: Assumptions & Uncertainty Part 4: The Emotional Conclusion The emotional finale is here! Don’t worry, this isn’t about curling up in a ball and crying – we’ve already done that. This final installment of my series on project estimating is all about navigating the emotions of everyone involved and trying to avoid frustration.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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How cells habituate

Science Daily: Pharmacology News

Up until recently, habituation -- a simple form of learning -- was deemed the exclusive domain of complex organisms with brains and nervous systems, such as worms, insects, birds, and mammals. But a new study offers compelling evidence that even tiny single-cell creatures such as ciliates and amoebae, as well as the cells in our own bodies, could exhibit habituation akin to that seen in more complex organisms with brains.

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Want to Lower Chemical Exposures in Pregnancy? Quit Nail Polish, Makeup and Hair Dye

Drugs.com

TUESDAY, Nov. 19, 2024 -- Women who won't leave the house without makeup or a spritz of hairspray may want to think twice about those habits when they're pregnant or breastfeeding.New research links these and other personal care products, including.

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FDA endorses speedy approval path for Regenxbio Duchenne gene therapy

BioPharma Drive: Drug Pricing

The agency's openness to a targeted pivotal study shows it’s still willing to consider accelerated clearance for Duchenne gene therapies despite questions about their effectiveness.

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Redefining net zero will not stop global warming

Science Daily: Pharmacology News

An international group of authors who developed the science behind net zero demonstrate that relying on 'natural carbon sinks' like forests and oceans to offset ongoing CO2 emissions from fossil fuel use will not actually stop global warming. The science of net zero, developed over 15 years ago, does not include these natural carbon sinks in the definition of net human-induced CO2 emissions.

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Ablation Best Treatment for Rapid Heartbeat in Heart Attack Survivors

Drugs.com

TUESDAY, Nov. 19, 2024 -- New research suggests that a procedure now regarded as Plan B when patients have episodes of rapid heartbeat after a heart attack should be the go-to treatment.Ablation is a minimally invasive procedure to treat abnormal.

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Some Thoughts on Splitting Chemical Datasets

Practical Cheminformatics

Introduction Dataset splitting is one topic that doesn’t get enough attention when discussing machine learning (ML) in drug discovery. The data is typically divided into training and test sets when developing and evaluating an ML model. The model is trained on the training set, and its performance is assessed on the test set. If hyperparameter tuning is required, a validation set is also included.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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The Future of Partnerships in Generic Drug Development

Drug Patent Watch

The pharmaceutical industry is undergoing significant transformations, particularly in the realm of generic drug development. Recent trends and advancements in technology, research, and collaboration are reshaping the landscape of generic drug development, leading to new opportunities and challenges for pharmaceutical companies.

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Dieting: Cause of the yo-yo effect deciphered

Science Daily: Pharmacology News

Researchers have discovered a mechanism behind the yo-yo effect: fat cells have a memory that is based on epigenetics.

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Most of the World's Cities Lack Enough Trees to Cool, Calm Residents

Drugs.com

TUESDAY, Nov. 19, 2024 -- As climate changes sends summer temperatures higher worldwide, new research finds most urban residents don't have a key source of cooling shade: trees.A study of eight cities around the globe found that only two -- Seattle.

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Flagship, Pfizer alliance yields two more startup deals

BioPharma Drive: Drug Pricing

Pfizer will work with Ampersand Biomedicines and Montai Therapeutics to find drugs for obesity and lung cancer, respectively, adding to collaborations it previously formed with other Flagship startups.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Large Chains’ Position in 2025’s Part D Pharmacy Networks: Supermarkets Take the Lead in a Shrinking PDP Market

Drug Channels

In Medicare Part D in 2025: Preferred Pharmacy Networks Fade in a Collapsing PDP Market , I documented the Inflation Reduction Act’s (IRA) disruption to Medicare Part D prescription drug plans (PDPs). Today, we examine the seven largest retail chains’ participation in the 12 major 2025 Part D networks that the five largest plan sponsors will offer. As always, we provide you with a handy table for tallying each chain’s participation and changes from 2024 to 2025.

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Scientists recreate mouse from gene older than animal life

Science Daily: Pharmacology News

An international team of researchers has achieved an unprecedented milestone: the creation of mouse stem cells capable of generating a fully developed mouse using genetic tools from a unicellular organism, with which we share a common ancestor that predates animals. This breakthrough reshapes our understanding of the genetic origins of stem cells, offering a new perspective on the evolutionary ties between animals and their ancient single-celled relatives.

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More Than Half of U.S. Adults Could Be Candidates for Ozempic

Drugs.com

TUESDAY, Nov. 19, 2024 -- More than half of all American adults, almost 137 million people, could be candidates for the blockbuster GLP-1 drug semaglutide, a new analysis finds.Sold as Ozempic for treating diabetes and Wegovy to spur weight loss.

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Chasing new ‘checkpoints,’ startup Valora emerges from a Nobel winner’s lab

BioPharma Drive: Drug Pricing

Built around research by Stanford scientist Carolyn Bertozzi and MIT researcher Jessica Stark, Valora Therapeutics is designing drugs to target glyco-immune checkpoints.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Can drugs be blockbusters without relying on US sales?

Drug Patent Watch

The concept of a blockbuster drug, defined as a medication generating at least $1 billion in annual sales, has long been a cornerstone of the pharmaceutical industry. However, the question arises whether a drug can achieve blockbuster status without heavily relying on U.S. sales.

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Effortless robot movements

Science Daily: Pharmacology News

Humans and animals move with remarkable economy without consciously thinking about it by utilizing the natural oscillation patterns of their bodies. A new tool can now utilize this knowledge for the first time to make robots move more efficiently.

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Climate Change to Blame for Almost 1 in 5 New Dengue Infections

Drugs.com

MONDAY, Nov. 18, 2024 -- One in five cases of dengue fever can be linked to climate change, and future surges in the mosquito-borne virus are inevitable, a new study says.About 19% of current dengue cases can be tied to climate change, which has.

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Sage’s string of research failures continues

BioPharma Drive: Drug Pricing

Negative results from a Huntington’s trial add to a calamitous year for Sage, which last month decided to overhaul its research, reconfigure its executive team and lay off a third of its staff.

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Atlas Venture 2024 Year In Review

LifeSciVC

“May you live in interesting times” – or so goes the phrase. In 1966, RFK Jr’s father famously used that quote to capture the turbulence of the times, and continued: “Like it or not, we live in interesting times. They are times of danger and uncertainty, but they are also the most creative of any time in the history of mankind.” Ironically, this is how biotech feels right now in November 2024, dealing with the shockwaves of Trump’s nomination of RFK Jr as the nation’s new health czar.

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Gaming for the good!

Science Daily: Pharmacology News

It turns out gaming is good for you! New research indicates massive multiplayer online gamers learn by gaming and their skills in the workplace are enriched by those seemingly endless hours previously thought of as frittering away time.

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New Prolapse Surgery Uses Women's Own Tissues to Restore Function

Drugs.com

MONDAY, Nov. 18, 2024 -- It’s possible to correct a woman’s pelvic prolapse using her own muscle tissue in robot-assisted surgery, a new study demonstrates.In the procedure, tendon muscle is transferred from the thigh to the uterus or cervix, rep.

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Reducing variability in gene expression: bottlenecks and solutions

BioPharma Drive: Drug Pricing

Explore solutions to reduce variability in gene expression during cell line development.

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The Future of Generic Drug Development in Emerging Markets

Drug Patent Watch

The pharmaceutical industry is undergoing a significant shift, with emerging markets offering the next growth opportunity. This growth is driven by several factors, including the increasing prevalence of chronic diseases, cost-effectiveness, and patent expirations of branded drugs.

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The chilling sound of the Aztec death whistle

Science Daily: Pharmacology News

The Aztec skull whistle produces a shrill, screaming sound. A study shows that these whistles have a disturbing effect on the human brain. The Aztecs may have deliberately used this effect in sacrificial rituals.

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Newer Blood Thinner, Edoxaban, Cuts Odds for Stroke After Heart Valve Surgery

Drugs.com

TUESDAY, Nov. 19, 2024 -- Japanese researchers say they have found a pill that works as well as existing medication to prevent blood clots after heart valve surgery, with fewer trips to the doctor. Unlike warfarin, the standard treatment, edoxaban.

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Syndax secures FDA OK for new kind of leukemia drug

BioPharma Drive: Drug Pricing

Revuforj is the first so-called menin inhibitor cleared in the U.S., securing FDA approval for use in adults and certain pediatric patients with an aggressive form of acute leukemia.

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Adaptive by Design: The Promise of Generative Interfaces

Perficient: Drug Development

Imagine a world where digital interfaces anticipate your needs, understand your preferences, and adapt in real-time to enhance your experience. This is not a futuristic daydream, but the promise of generative interfaces. Generative interfaces represent a new paradigm in user experience design, moving beyond static layouts to create highly personalized and adaptive interactions.

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Earliest evidence of humans using fire to shape the landscape of Tasmania

Science Daily: Pharmacology News

Some of the first human beings to arrive in Tasmania, over 41,000 years ago, used fire to shape and manage the landscape, about 2,000 years earlier than previously thought.

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Certain Painkillers Can Raise Bleeding Risks for People on Blood Thinners

Drugs.com

MONDAY, Nov. 18, 2024 -- People on blood thinners have a doubled risk of dangerous internal bleeding if they also take a non-steroidal anti-inflammatory drug (NSAID) like ibuprofen or naproxen, a new study warns.People typically are prescribed.