Drugs.com

AUGUST 2, 2024

2, 2024 -- Mpox cases have soared by 160% in Africa this year, as a lack of both vaccines and treatments hamper efforts to slow the spread of the virus.In FRIDAY, Aug. a report released by the Africa Centers for Disease Control and Prevention on.

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Science Daily: Pharmacology News

JUNE 14, 2024

The amount of infectious H5N1 influenza viruses in raw milk rapidly declined with heat treatment in laboratory research. However, small, detectable amounts of infectious virus remained in raw milk samples with high virus levels when treated at 72 degrees Celsius (161.6

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National Drug & Alcohol Research Centre Blog

DECEMBER 4, 2023

Kendal Chidwick NDARC’s Kendal Chidwick discusses the findings from a recently published study that examined how patterns of opioid agonist treatment medicines have changed over the past decade. Other changes around this time aimed at improving treatment accessibility included increased use of take-home doses and telehealth appointments.

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Drug Target Review

DECEMBER 13, 2024

2 Unmet needs in lung cancer treatment Recent decades have seen significant advancements in lung cancer treatment, especially with the introduction of targeted therapies and immunotherapies, which have notably improved survival rates. 18 Indeed, early-phase clinical studies exploring TsAbs in solid tumours have recently commenced.

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Science Daily: Pharmacology News

JUNE 18, 2024

The discovery could lead to more targeted treatments, with fewer side-effects, for issues from lengthy COVID infections to autoimmune diseases like multiple sclerosis. Current anti-inflammatory drugs used for this purpose suppress the body's whole immune system, making patients more vulnerable to infection.

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Drugs.com

NOVEMBER 5, 2024

5, 2024 -- Current treatments sometimes fail to help people with “wet” age-related macular degeneration -- and researchers now think they know why.Wet AMD is caused by an overgrowth of blood vessels in the retina, the light-sensing tis. TUESDAY, Nov.

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BioPharma Drive: Drug Pricing

OCTOBER 9, 2024

Many pharma companies are now using de-identified lab data to identify potential patients and their physicians in time to impact the patient’s treatment plan. In this Q&A, learn how lab data can be used to increase patient access.

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Science Daily: Pharmacology News

JUNE 20, 2024

Scientists have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese.

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Treatment 131

Chemical Biology and Drug Design

AUGUST 15, 2024

The findings reveal the active constituents, key targets, and molecular mechanisms of myrrh in BC treatment, providing scientific evidence that supports the role of myrrh in BC therapy. ABSTRACT This study aimed to investigate the mechanism of action of myrrh in breast cancer (BC) treatment and identify its effective constituents.

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Drugs.com

OCTOBER 11, 2024

FRIDAY, Oct. 11, 2024 -- Endometriosis could be linked to the health of a woman’s microbiome, a new study says. The discovery might help lead to an early test for the painful condition, and possible new treatments.A specific set of bacteria in w.

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Drugs.com

NOVEMBER 22, 2024

FRIDAY, Nov. 22, 2024 -- A daily dose of vitamin B3 reduced inflammation in the lungs of patients with COPD, Danish researchers report. This is significant, because inflammation can lead to reduced lung function in these patients," said researcher.

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BioPharma Drive: Drug Pricing

DECEMBER 20, 2023

The Healey center is at the front of ALS research and care, earning acclaim from patients, doctors and scientists. Still, the complexities of the disease and of drug development have brought hard-felt losses.

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Science Daily: Pharmacology News

MARCH 7, 2024

Four children have remained free of detectable HIV for more than one year after their antiretroviral therapy (ART) was paused to see if they could achieve HIV remission, according to new research.

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ASPET

SEPTEMBER 20, 2024

Current pharmacological treatments for PTSD are insufficient, with fewer than 30% of patients reporting symptom remission. Treatments began 4 hours after FC. This study contributes to the existing literature on pharmacological treatment for fear and anxiety behaviors relating to fear memory and fear generalization.

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Treatment Research 190

BioPharma Drive: Drug Pricing

MARCH 12, 2024

Physicians are preparing for tough conversations with patients on Amylyx Pharmaceuticals’ drug, Relyvrio, while holding out hope it still may help some with the disease.

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ASPET

SEPTEMBER 16, 2024

GBM has a poor prognosis despite aggressive treatment, in part due to lack of adequate drug permeability at the BBB. Acknowledging the potential for inter-species differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

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Drugs.com

NOVEMBER 28, 2024

THURSDAY, Nov. 28, 2024 -- Geoffrey Pointing says its hard to describe the distress of an asthma or COPD flare-up.“Honestly, Honestly, when you're having a flare up, it's very difficult to tell anybody how you feel - you can hardly breathe,” Pointing, 77, of.

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Treatment 109

Drugs.com

DECEMBER 13, 2024

FRIDAY, Dec. 13, 2024 -- The ancient Japanese practice of reiki "energy healing" might help some cancer patients deal with the pain that can come with infusion therapies, new research shows. Outpatients receiving reiki during infusion reported.

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BioPharma Drive: Drug Pricing

APRIL 10, 2024

The first medicine approved for PPD, Sage’s Zulresso, never gained traction. The company is in the midst of launching its second, but long-standing challenges could slow uptake.

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Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 4, 2024 -- An experimental three-in-one blood pressure pill works better than layering on meds one at a time, a new clinical trial shows.After a month on the combo pill, 81% of patients had their blood pressure under control.

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Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- Iron deficiency isn’t being effectively treated in the United States, with low iron levels persisting for years in most patients, a new study finds.Almost 3 of 5 (58%) patients with iron deficiency still had low iron levels.

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Treatment 113

Drugs.com

DECEMBER 5, 2024

THURSDAY, Dec. 5, 2024 -- “An ounce of prevention is worth a pound of cure,” founding father Benjamin Franklin once said.That’s definitely true of cancer, a new study has found.Cancer prevention and screening has saved more people from five types of.

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Treatment 94

ASPET

OCTOBER 23, 2024

These results further demonstrate the utility of pH-dependent neuroprotective agents and GluN2B-selective NMDAR inhibitors as potential therapeutic strategies for the treatment of aSAH. Based on allometric scaling of both toxicological and efficacy data, the therapeutic margin in man should be at least 2.

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Clinical Development Treatment Pharmacokinetics Drugs 100

Science Daily: Pharmacology News

MARCH 27, 2024

Scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein. Scientists discovered that removing a second protein from cancer cells already experiencing tumor suppressor loss can reverse cancer cell identity.

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Treatment Research 118

Chemical Biology and Drug Design

SEPTEMBER 20, 2023

The combined treatment successfully enhanced cisplatin cytotoxicity and helped to overcome cisplatin resistance in CR-Caov3 cells. Most patients experience recurrence and succumb eventually to resistant disease, underscoring the need for an alternative treatment option.

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Treatment Disease Research 190

FDA Law Blog: Drug Discovery

NOVEMBER 10, 2024

Food and Drug Administration (FDA) plays a pivotal role in fostering the development of treatments for rare diseases through its Orphan Products Grants Program. The Natural History Studies Grants Program funds natural history studies that collect gather data on how rare diseases progress over time without treatment.

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BioPharma Drive: Drug Pricing

JUNE 26, 2024

Obesity drugs like Wegovy are proving useful in many other diseases. Polycystic ovary syndrome, a chronic condition that can cause infertility, may be one.

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Treatment Drugs Disease 126

Drugs.com

NOVEMBER 19, 2024

TUESDAY, Nov. 19, 2024 -- New research suggests that a procedure now regarded as Plan B when patients have episodes of rapid heartbeat after a heart attack should be the go-to treatment.Ablation is a minimally invasive procedure to treat abnormal.

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Treatment Research 97

Drugs.com

OCTOBER 10, 2024

THURSDAY, Oct. 10, 2024 -- More than 15.5 million U.S. adults have been diagnosed with ADHD, and nearly three-quarters of those taking medication to treat it say drug shortages are hampering their ability to get help, a new report finds. According.

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Treatment Drugs 105

Chemical Biology and Drug Design

JANUARY 4, 2024

Herein, we treated SW620 and HT-29 CRC cells with different curcumin concentrations, followed by treatment with the half maximal inhibitory concentration (IC50) curcumin/endoplasmic reticulum stress (ERS) inhibitor 4-phenyl butyric acid (4-PBA)/activating transcription factor 6 (ATF6) interference plasmid (si-ATF6).

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Regulations Treatment Research 189

Drug Discovery Today

OCTOBER 2, 2024

Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer’s disease, and improve symptoms of neurodegeneration in mice.

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Therapies Disease Treatment 113

Drug Target Review

DECEMBER 23, 2024

While these therapies hold great promise for improving cancer treatment outcomes, their development presents significant challenges, especially in achieving the optimal balance between efficacy and safety. Properly managing these toxicities is crucial to enhancing the safety and therapeutic effectiveness of ADC treatments.

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Research Treatment Therapies Drug Development 52

Science Daily: Pharmacology News

SEPTEMBER 27, 2024

The risk of being born with a major heart defect is 36% higher in babies who were conceived after assisted reproductive technology, such as in vitro fertilization (IVF), according to results of a very large study.

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Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- Patients who lose the use of their hands and arms after a stroke or traumatic brain injury could regain some function through deep brain stimulation (DBS), new research demonstrates.DBS involves surgical placement of.

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Treatment Research 96

ASPET

JUNE 4, 2024

The 8 -THC treatment (30 mg/kg) reduced paw swelling and qualitative signs of arthritis. These data support the development of novel cannabinoid treatments for inflammatory arthritis.

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Drug Hunter

AUGUST 15, 2023

On Sunday, it was disclosed that additional, likely on-target adverse findings were observed in a primate GLP study on long-term treatment with Merck’s second-generation LRRK2 inhibitors. II (NCT05348785) after demonstrating safety and CNS exposure in 145 healthy patients in Ph. I ( NCT04557800 ).

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Chemical Biology and Drug Design

NOVEMBER 10, 2024

ABSTRACT This study aimed to explore the pathogenesis of platycodin D and luteolin, which are both active components in Jiegeng ( Platycodonis Radix ), in the treatment of influenza virus pneumonia through network pharmacology analysis combined with experimental verification.

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